ArticleIndian journal of dermatology
A Cross-sectional Study Comparing the
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: In India, Objective: This study aimed to evaluate biofilm formation in dermatophyte isolates and explore its correlation with demographic factors, disease duration, steroid misuse, and antifungal resistance to facilitate future management strategies. Materials and Methods: A total of 65 patients with clinically diagnosed dermatophytosis were included in this tertiary care center-based study. Detailed clinical histories were documented, and biofilm formation was quantified using crystal violet staining. Antifungal susceptibility testing was performed according to CLSI M38-A2 guidelines. Clinical improvement was assessed using the Clinical Assessment Severity Score, and statistical analysis was performed to explore associations between biofilm formation, clinical response, and antifungal resistance. Results: Conclusion: Our findings underscore the role of biofilm formation in contributing to chronic and recurrent dermatophytosis, particularly in patients with a history of oral antifungal use. Biofilm density correlates significantly with antifungal resistance, which may hinder clinical outcomes. These results highlight the need for tailored treatment strategies targeting biofilm-associated resistance to improve the management of chronic dermatophytosis.
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