ArticleFrontiers in endocrinology2025
The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
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Abstract
Background: Oxidative stress and metabolic disorders significantly contribute to the development of polycystic ovarian syndrome (PCOS). Heme oxygenase-1 (HMOX1) plays a key role in the degradation of heme and the regulation of oxidative stress, ferroptosis, and glycolipid metabolism. This study explored the relationship between Methods: This case-control study included 1092 women diagnosed with PCOS and 805 controls. The (GT)n and rs2071746 polymorphisms were identified using polymerase chain reaction amplification, followed by capillary electrophoresis or restriction fragment length polymorphism. HMOX1 levels and clinical, metabolic, hormonal, and oxidative stress indices were analyzed. Results: The Conclusion:
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