Evidence map›Paper›PMID 41262169›Full record

ArticleCase reports in hematology2025

How Early Is Too Early? Use of Lineage-Specific Chimerism in Early Detection of Donor-Derived Malignancy After Allogeneic Stem Cell Transplant: A Case Report.

Victor Zaman-Pope, Adrienne Fulford, Uday Deotare, Shona Philip, Christopher Burnie, Angela Hardeman, Anargyros Xenocostas, Anahita Mohseni Meybodi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victor Zaman-PopeDepartment of Medicine, Division of Hematology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0001-5040-2364
Adrienne FulfordDepartment of Medicine, Division of Hematology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Uday DeotareDepartment of Medicine, Division of Hematology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Shona PhilipDepartment of Medicine, Division of Hematology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Christopher BurniePathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.
Angela HardemanPathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.
Anargyros XenocostasDepartment of Medicine, Division of Hematology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-6506-9637
Anahita Mohseni MeybodiPathology and Laboratory Medicine, London Health Sciences Centre, London, Ontario, Canada.ORCID https://orcid.org/0000-0001-9049-8057

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic stem cell transplant is critical for treatment of certain hematologic malignancies. However, it has significant risks including relapsed malignancy, infection, and graft versus host disease. Rarely, de novo malignancy can arise from donor cells. Chimerism analysis is used to monitor engraftment and predict rejection or disease relapse. Our patient underwent an allogeneic transplant for myelodysplastic syndrome but had persistent pancytopenia despite donor lymphocyte infusion. This was due to donor-derived malignancy, which was predicted by loss of a satellite marker on chimerism analysis 6 months prior. This could have allowed earlier intervention and underscores the importance of detailed chimerism monitoring.

Identifiers

PMID41262169
PMCPMC12626685

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.