Evidence map›Paper›PMID 41262077›Full record

ArticleWorld journal of gastrointestinal oncology2025

Methionyl-tRNA synthetase 1 participates in hepatocellular carcinoma and its regulated gene profile possesses potent prognostic ability.

Hai-Yan Bu, Hong Huang, Jia Li, Ze-Bing Huang, Yan Huang, Yu-Kun Huang, Ai-Min Wang, Li Wu, Jiao Yuan, Rong-Jun Wang and 6 more

Abstract read
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In one paragraph

Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hai-Yan BuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Hong HuangSchool of Medicine, Guilin Medical University, Guilin 541199, Guangxi Zhuang Autonomous Region, China.
Jia LiDepartment of Emergency Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Ze-Bing HuangDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Yan HuangDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Yu-Kun HuangDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Ai-Min WangDepartment of Emergency Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Li WuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Jiao YuanDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Rong-Jun WangSchool of Medicine, Guilin Medical University, Guilin 541199, Guangxi Zhuang Autonomous Region, China.
Min LuDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410000, Hunan Province, China.
Song-Man YuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Pan-Pan YiDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Ya-Yu ChenHunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Yu-Peng JiangDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha 410000, Hunan Province, China.
Xing-Wang HuDepartment of Infectious Diseases, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is a significant global health challenge with rising incidence rates and poor prognoses. Aminoacyl-tRNA synthetases (ARSs) are important regulators implicated in the occurrence and progression of several cancers. However, their specific function in HCC remains unclear, and

aimTo investigate the ARSs-related mechanisms of HCC and establish an effective prognostic risk model for stratifying patients with HCC.

methodsWe screened

results

conclusionMARS1 promotes HCC development and represents a potential therapeutic target for HCC management. Furthermore, MRPS serves as an independent prognostic factor for survival and a predictor of tumor treatment response.

Indexed as

Aminoacyl-tRNA synthetasesBioinformaticsHepatocellular carcinomaMethionyl-tRNA synthetase 1Prognostic model

Identifiers

PMID41262077
PMCPMC12624232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.