Evidence map›Paper›PMID 41262011›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease.

Yue-Han Chen, Rong-Xin Zhu, Nuo-Xi Zhang, Ting-Ting Sun, Xi-Wei Zhang, Yu-Jie Zhao, Ben-Yu He, Hang Yao, Ren-Hong Du, Lei Cao and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yue-Han ChenJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Rong-Xin ZhuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Nuo-Xi ZhangDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China.
Ting-Ting SunJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Xi-Wei ZhangJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Yu-Jie ZhaoJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Ben-Yu HeJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Hang YaoJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Ren-Hong DuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Lei CaoJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Wen-Bin ZhangDepartment of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu, 210029, China.
Wei-Guo LiuDepartment of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, Jiangsu, 210029, China.
Yun CaiDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China.
Cong WangJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Gang HuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.
Yao WeiDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China.
Yang LiuDepartment of Pharmacology, School of Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China.
Ming LuJiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, 211116, China.ORCID https://orcid.org/0000-0001-8018-8389

Funding

Basic Research Program of Jiangsu, Jiangsu Province lnnovation center for Brain-Inspired intelligence technology BM2024001National Key R&D Program of China 2021ZD0202903National Natural Science Foundation of China 82373851Open fund of state key laboratory of Pharmaceutical Biotechnology, Nanjing University, China KF-202502Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX25_2193Traditional Chinese Medicine Science and Technology Development Youth Foundation of Jiangsu Province QN202407
6 · The paper itself

Abstract

Serine Hydroxymethyltransferase 1 (SHMT1) plays a pivotal role in one-carbon metabolism, facilitating the production of SAM. In this study, dysregulation of one-carbon metabolism is reported in both Parkinson's disease (PD) patients and animal models, characterized by significantly downregulated expression of SHMT1. Astrocyte-specific conditional knockout of Shmt1 decreased SAM level, exacerbated motor dysfunction, and dopaminergic neuronal loss in a PD mouse model. While SAM is conventionally generated through the one-carbon cycle, the data indicate that, despite significant alterations in SHMT1, SAM remains unaffected while labeled

Indexed as

AstrocytesGlycine HydroxymethyltransferaseParkinson DiseasePhosphatidylethanolamine N-MethyltransferaseAnimalsDisease Models, AnimalHomeostasisHumansMaleMiceMice, KnockoutGlycine HydroxymethyltransferasePhosphatidylethanolamine N-MethyltransferaseSHMT protein, humanneuroexcitotoxicityone‐carbon metabolismparkinson's diseaseSAMSHMT1/PEMT

Identifiers

PMID41262011
PMCPMC12866788

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.