Evidence map›Paper›PMID 41262005›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Subicular Astrocytes Govern Seizure-Impaired Fear Memory.

Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Subicular Astrocytes Govern Seizure-Impaired Fear Memory.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuying ShaoKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Jing XiKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Yuhao SunKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Yulan LiZhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Zhisheng LiKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Wangjialu LuKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Jialu ChenKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Lin YangZhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Fan FeiZhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Heming ChengZhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Li ChengZhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Cenglin XuZhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Zhuo HuangState Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China.
Vladimir ParpuraInternational Translational Neuroscience Research Institute, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Yi WangKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0002-1350-2961
Zhong ChenKey Laboratory of Medical Neurobiology of the Ministry of Health of China, Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0003-4755-9357

Funding

National Natural Science Foundation of China 82330116National Natural Science Foundation of China U23A20533Natural Science Foundation of Zhejiang Province LD24H310001
6 · The paper itself

Abstract

The mechanisms underlying seizure-associated cognitive impairment remain incompletely characterized. Emerging evidence positions the subiculum, a hippocampal output hub critically involved in both epileptic seizure and cognitive performance, as a putative nexus for this comorbidity. Here, it is demonstrated that astrocytic activation in the subiculum mediates seizure-induced fear memory deficits. Subicular astrocytes dynamically respond to conditioned fear memory learning, acting as a "scavenger" for the inhibition of context memory. Seizure activity hyperactivates these leaning-associated astrocytes and amplifies their engagement during fear processing. Suppression of subicular astrocyte Ca

Indexed as

AstrocytesFearHippocampusMemoryMemory DisordersSeizuresAdenosineAnimalsMaleMiceMice, Inbred C57BLAdenosineastrocytesepilepsyfear memoryseizuresubiculum

Identifiers

PMID41262005
PMCPMC12866762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.