ReviewCardiovascular research2025
In vitro approaches to mimic cardiac mechanical load dynamics for enhancing maturation and disease modelling.
Review in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cyclic Mechanical Loading of Cardiomyocytes via Pressure-Driven Non-Planar Membrane Deformation in a Bioreactor System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Restoring anisotropy after myocardial injury: strategies to align transplanted human induced pluripotent stem-cell-derived cardiomyocytes.Experimental & molecular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The use of human pluripotent stem cells in cardiac tissue engineering has led to significant advances in the development of in vitro models of the human heart. However, full maturation of human pluripotent stem cell-derived cardiomyocytes has not been achieved. Current maturation strategies aim to replicate the native cardiac environment by incorporating the passive and active mechanical cues of the heart. Cardiac preload and afterload are key active mechanical loads that directly influence cardiomyocyte maturation and overall cardiac function. In this review, we explore the role of mechanical stimuli in cardiac development and cardiomyocyte maturation, with a focus on how preload and afterload dynamics can be replicated in vitro using platforms such as engineered heart tissues, stretchable membranes, bioactuators, engineered cardiac chambers, and microtissues. Additionally, we highlight the role of stimulation parameters used in dynamic preload modelling and how the incorporation of these active mechanical loads is applied in disease modelling.
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Registered trials
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