Trial reportPhysiological reports2025
Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study.
Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study.Physiological reports · 2025Trial
- Review
- Coffee as a polypharmacological modulator of mitochondrial health: from molecular mechanisms to translational implications.Journal of translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endurance exercise may be associated with acute damage to intestinal epithelial cells. The effect of caffeine supplementation, and whether this is influenced by common genetic polymorphisms (ADORA2A: rs5751876 and CYP1A2: rs762551), is not currently known. Participants (n = 18 men and women) ingested caffeine (3 mg/kg body mass) or placebo 45 min before cycling (20 min at 70% maximal oxygen uptake followed by a 15-min performance time-trial). Plasma intestinal fatty acid binding protein (iFABP) was measured pre-supplementation, pre- and post-exercise. Four-way mixed ANOVAs revealed significant main effects of treatment, time, and treatment × time interaction (p < 0.05). Post hoc tests revealed a post-exercise increase in plasma [iFABP], which was greater with caffeine; and a trial × ADORA2A genotype interaction p = 0.021, with further post hoc analysis revealing a significant post-exercise increase only in ADORA2A TT ("high sensitivity") participants in the caffeine trial (increase ~109%, p = 0.027, vs. 48% increase p > 0.05 for "low sensitivity" participants). There were no other main effects or interactions (all p > 0.05). Acute damage to gut cells caused by endurance exercise may be exacerbated by caffeine, especially in sensitive individuals. The potential implications of this for gastrointestinal responses to exercise warrant further examination.
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Registered trials
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