Evidence map›Paper›PMID 41261890›Full record

ArticleJournal of leukocyte biology2025

Differential roles for Irgm1 in myeloid cells for immune resistance to pathogenic bacteria.

Brian E Fee, Lanette R Fee, Aemilia R Sprouse, Bruce A Vallance, Prashant Rai, Michael B Fessler, Yue Xue, Hsin-I Huang, Gianna E Hammer, Gregory A Taylor

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brian E FeeDepartment of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, PO Box 3003, Durham, NC 27710, United States.
Lanette R FeeDepartment of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, PO Box 3003, Durham, NC 27710, United States.
Aemilia R SprouseDepartment of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, PO Box 3003, Durham, NC 27710, United States.
Bruce A VallanceDepartment of Pediatrics, Division of Gastroenterology, BC Children's Hospital Research Institute, 4480 Oak Street, Vancouver, BC, Canada V5Z 4H4.ORCID 0000-0003-1345-6747
Prashant RaiImmunity, Inflammation and Disease Laboratory, NIEHS, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, United States.
Michael B FesslerImmunity, Inflammation and Disease Laboratory, NIEHS, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, United States.
Yue XueDepartment of Integrative Immunobiology, Duke University Medical Center, PO Box 3010, Durham, NC 27710, United States.
Hsin-I HuangDepartment of Integrative Immunobiology, Duke University Medical Center, PO Box 3010, Durham, NC 27710, United States.
Gianna E HammerDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, 15 North Medical Drive East, Suite #1100, Salt Lake City, UT 84112, United States.
Gregory A TaylorDepartment of Medicine, Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, PO Box 3003, Durham, NC 27710, United States.ORCID 0000-0003-1966-0917

Funding

Cell Signaling of Host DefenseZ01ES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2006 to 2008
$3.3M
IRGM proteins as regulators of inflammationR01AI148243 · NIAID · DUKE UNIVERSITY · PI COERS, JOERN, TAYLOR, GREGORY A · 2020 to 2024
$2.4M
Role of IRGM proteins in immunity to enteric bacteriaR01AI145929 · NIAID · DUKE UNIVERSITY · PI TAYLOR, GREGORY A · 2019 to 2023
$1.6M
Foundation Chair in Pediatric Gastroenterologyhildren with Intestinal and Liver DisordersIntramural NIH HHS Z01 ES102005NIAID NIH HHS R01 AI145929NIAID NIH HHS R01 AI148243NIEHS NIH HHSNIH HHS AI145929NIH HHS AI148243NIH HHS Z01 ES102005
6 · The paper itself

Abstract

IRGM proteins are associated with increased susceptibility to Crohn's disease, mycobacterial infections, sepsis, and other inflammatory diseases, but the cells in which they function in vivo have not been delineated. To address this, mice with conditional deletions of Irgm1 were created and challenged with model pathogens. Irgm1fl/flLyz2-Cre+ mice (a myeloid deletion) displayed marked susceptibility to infections with Salmonella typhimurium, Listeria monocytogenes, and Toxoplasma gondii, paralleling those of global Irgm1-/- mice. However, infections of Irgm1fl/flLyz2-Cre+ mice with Citrobacter rodentium showed no increase in susceptibility, contrasting with marked increases in Irgm1fl/flVav-Cre+ mice (a hematopoietic deletion). Macrophages from Irgm1fl/flLyz2-Cre+ mice displayed pathologies present in macrophages from global Irgm1-/- mice, validating the conditional deletion in myeloid cells. These results suggest that Irgm1 functioning in myeloid cells is critical for immune resistance to intracellular pathogens, while Irgm1 functioning in additional hematopoietic population(s) is required for resistance to extracellular pathogens in the intestinal lumen.

Indexed as

Disease ResistanceGTP-Binding ProteinsMyeloid CellsAnimalsCitrobacter rodentiumListeria monocytogenesMacrophagesMiceMice, Inbred C57BLMice, KnockoutSalmonella typhimuriumToxoplasmaGTP-Binding ProteinsIfi1 protein, mousebacteriaGTPaseinterferonmacrophage

Identifiers

PMID41261890
PMCPMC12723655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.