ArticleCancer reports (Hoboken, N.J.)2025
Development of a Predictive Model for Large-Volume Pleural Effusion After Separation Surgery in Patients With Spinal Metastatic Tumors.
Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Development of a Predictive Model for Large-Volume Pleural Effusion After Separation Surgery in Patients With Spinal Metastatic Tumors.Cancer reports (Hoboken, N.J.) · 2025Article
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9 authors.
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Abstract
backgroundSeparation surgery followed by radiotherapy has emerged as a prevalent approach for managing spinal metastatic tumors. However, large-volume postoperative pleural effusion (POPE) represents a challenging complication, as it potentially delays subsequent treatments and increases morbidity. This study aims to identify risk factors for large-volume POPE and develop a predictive model for early identification to improve patient prognosis.
methodsThis retrospective study analyzed 443 patients who underwent separation surgery for spinal metastases at our center between January 2014 and January 2022. High-resolution CT-based 3D modeling was utilized for accurate pleural effusion (PE) volume quantification. Variables including patient demographics, surgical details, and laboratory results were examined to identify risk factors associated with large-volume POPE (≥ 1000 mL). A predictive nomogram was developed based on the multivariate logistic regression analysis.
resultsOur findings indicated that advanced age, increased intraoperative blood loss, and decreased levels of preoperative serum albumin, postoperative serum protein, and hemoglobin were significant independent risk factors for large-volume POPE. The predictive nomogram demonstrated high accuracy, with a mean AUC value of 0.953 for the training dataset and 0.927 for the testing dataset, indicating reliable predictability for identifying patients at high risk for large-volume POPE.
conclusionOur study identified independent risk factors for large-volume PE following separation surgery in patients with spinal metastasis. The developed nomogram offers a practical tool for early identification of high-risk groups, enabling timely and targeted interventions. By reducing the risk of large POPE, this approach may shorten hospitalization and accelerate the resumption of postoperative treatment, ultimately improving patient prognosis.
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