ArticleEuropean journal of medical research2025
Threshold effect of systemic immune-response index on in-stent neoatherosclerosis among patients with drug-eluting stent restenosis.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association of systemic inflammatory index and HbA1c with in-stent restenosis in arteriosclerosis obliterans patients after stenting: a propensity score-matched analysis.American journal of translational research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundIn-stent neoatherosclerosis (ISNA) is a key mechanism underlying drug-eluting stent in-stent restenosis (DES-ISR), with inflammation playing a critical role. This study aimed to assess the association between the systemic immune-response index (SIRI) and ISNA in DES-ISR patients.
methodsA retrospective analysis included 212 patients with DES-ISR who underwent coronary angiography and optical coherence tomography (OCT) at least 12 months after stent implantation. SIRI was calculated as (neutrophil count × monocyte count)/lymphocyte count and divided into tertiles. Multivariate logistic regression, smooth curve fitting, threshold effect, and subgroup analyses were performed to evaluate the relationship between SIRI and ISNA risk.
resultsHigher SIRI tertiles were associated with ISNA and thin-cap fibroatheroma (all P < 0.05). Multivariate analysis identified SIRI as an independent risk factor for ISNA (OR per unit increase 1.23, 95% CI 1.04-1.47, P = 0.018). Smooth curve fitting identified a non-linear association, highlighting a distinct threshold at a SIRI level of 3.95, below which the risk of ISNA rose sharply. Subgroup analysis revealed that the association between SIRI and ISNA risk was largely consistent across most subgroups, with a significant interaction observed only among patients younger than 60 years (OR 1.94, 95% CI 1.23-3.05, P for interaction = 0.010).
conclusionSIRI is independently and non-linearly associated with the risk of ISNA in DES-ISR patients, with a distinct inflection point observed at a SIRI value of 3.95, below which elevated SIRI levels were significantly correlated with increased ISNA risk. Prospective studies are needed for further validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.