Evidence map›Paper›PMID 41261371›Full record

ArticleMagnetic resonance in medicine2026

Analytical Dual Flip Angle R1 Calculation Outside the Small-Angle Regime.

Luke J Edwards, Kerrin J Pine, Ilona Lipp, EBC consortium, Evgeniya Kirilina, Gunther Helms, Nikolaus Weiskopf

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luke J EdwardsDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID https://orcid.org/0000-0002-8320-7298
Kerrin J PineDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID https://orcid.org/0000-0002-2486-2970
Ilona LippDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID https://orcid.org/0000-0002-5644-2057
EBC consortium
Evgeniya KirilinaDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID https://orcid.org/0000-0003-1304-4363
Gunther HelmsDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Nikolaus WeiskopfDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Funding

Federal Ministry of Education and Research (BMBF) 01ED2210Horizon 2020 Framework Programme 681094Max-Planck-Gesellschaft M.IF.NEPF8103Seventh Framework Programme 616905
6 · The paper itself

Abstract

purposeTo evaluate a new analytical estimator for R1 and apparent proton density ( THEORY AND

methodsA rational approximation of the Ernst equation was derived for small

resultsThe small-angle approximation gave rise to a flip angle-dependent bias in all cases. This bias was not observed using the novel method, demonstrating its higher accuracy. There were only negligible differences in WCV between the methods, demonstrating that precision is preserved.

conclusionThe increase in accuracy and preservation of precision suggest that the novel method should be used instead of the current small flip angle method.

Indexed as

BrainImage Processing, Computer-AssistedMagnetic Resonance ImagingAdultAlgorithmsAnimalsComputer SimulationFemaleHumansMalePan troglodytesProtonsReproducibility of ResultsProtonsex vivo imagingin vivo histologylongitudinal relaxationT1 relaxometry

Identifiers

PMID41261371
PMCPMC12850634

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.