Evidence map›Paper›PMID 41261367›Full record

ArticleMagnetic resonance in chemistry : MRC2026

Usability of Amorphous Manganese Oxide for Assessing the Proteoglycan Content in Articular Cartilage.

Riikka M Korpi, Susanna Ahola, Gamzegul Behrouz, Eveliina Lammentausta, Sakari S Karhula, Simo Saarakkala, Lassi Rieppo, Mikko Finnilä, Siegfried Stapf, Jessica Rosenholm and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in chemistry : MRC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Riikka M KorpiDepartment of Radiology, Helsinki University Hospital, Helsinki, Finland.
Susanna AholaNMR Research Unit, University of Oulu, Oulu, Finland.
Gamzegul BehrouzNMR Research Unit, University of Oulu, Oulu, Finland.
Eveliina LammentaustaDepartment of Radiology, University of Oulu and Oulu University Hospital, Oulu, Finland.
Sakari S KarhulaDepartment of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland.
Simo SaarakkalaDepartment of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland.ORCID 0000-0003-2850-5484
Lassi RieppoDepartment of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland.
Mikko FinniläResearch Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Siegfried StapfDepartment of Technical Physics II/Polymer Physics, Institute of Physics, Ilmenau University of Technology, Ilmenau, Germany.
Jessica RosenholmPharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.ORCID 0000-0001-6085-1112
Roberto Blanco SequierosDepartment of Radiology, University of Turku and Turku University Hospital, Turku, Finland.
Miika T NieminenDepartment of Radiology, University of Oulu and Oulu University Hospital, Oulu, Finland.
Ville-Veikko TelkkiNMR Research Unit, University of Oulu, Oulu, Finland.ORCID 0000-0003-0846-6852

Funding

Academy of Finland 289649Academy of Finland 294027Academy of Finland 319216Academy of Finland 340099European Research Council 772110Kvantum Institute
6 · The paper itself

Abstract

Osteoarthritis (OA) is a highly common chronic disease that decreases functional capacity and can cause disability. The early detection of the disease could help to develop treatments that may reduce the progression if not cure the disease. Proteoglycan depletion is known to occur at an early state of OA and the delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) is currently considered as one of the most accurate methods for analyzing the depletion in articular cartilage (AC) despite the toxicity-related issues with gadolinium contrast agents. The aim of this study was to investigate the usability of amorphous manganese oxide (MnOx) for assessing the proteoglycan content in AC. The relaxation times of MnOx were determined at various fields and compared with the effect of gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) at 7.1 T. The diffusion of MnOx and Gd-DTPA into AC was analyzed ex vivo and followed for 24 h. Cartilage degeneration was evaluated with two histological scoring systems (OARSI and Mankin) to assess the relationship between OA severity and MnOx concentration. Relaxivity of MnOx was high and diffusion to the AC was faster than that of Gd-DTPA at 7.1 T. Using MnOx, T

Indexed as

Cartilage, ArticularManganese CompoundsOxidesProteoglycansAnimalsContrast MediaGadolinium DTPAHumansMagnetic Resonance ImagingOsteoarthritisContrast MediaGadolinium DTPAManganese Compoundsmanganese oxideOxidesProteoglycansarticular cartilagemagnetic resonance imagingmanganese oxide nanoparticlesproteoglycan

Identifiers

PMID41261367
PMCPMC12783944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.