Evidence map›Paper›PMID 41261363›Full record

ArticleJournal of movement disorders2026

Effective Botulinum Toxin Treatment in Patients With Different Patterns of Cervical Dystonia: A Retrospective SPECT and EMG Study.

Hongkai Gu, Yougui Pan, Lizhen Pan, Xiaolong Zhang, Ronghua Hong, Zhuang Wu, Chenghong Wang, Shuzhen Chen, Lingjing Jin, Fei Teng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of movement disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongkai GuNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yougui PanNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Lizhen PanNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiaolong ZhangNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Ronghua HongNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhuang WuNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Chenghong WangDepartment of Nuclear medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Shuzhen ChenDepartment of Nuclear medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Lingjing JinNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Fei TengNeurotoxin Research Center, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

National Clinical Key Specialty Construction Project of China Z155080000004National Key Research and Development Program of China 2023YFC3604500National Key Research and Development Program of China 2023Y FC3604505National Natural Science Foundation of China 32030047Shanghai Clinical Research Ward SHDC2023CRW018BShanghai Hospital Development Center Foundation SHDC22023304Shanghai Municipal Science and Technology 22Y31900200Shanghai Municipal Science and Technology 22Y31900203Shanghai Rehabilitation Medical Research Center 2023ZZ02027Shanghai Shenkang Hospital Development Center SHDC12020119
6 · The paper itself

Abstract

objectiveThe Col-Cap classification for cervical dystonia (CD) has been proposed to optimize treatment strategies with botulinum toxin type A (BTX-A). Although this concept has been used for 15 years, the efficacy of BTX-A in various CD patterns remains unclear. The present study compared the efficacy of BTX-A, aided by single-photon emission computed tomography (SPECT) and electromyography (EMG), in various CD patterns.

methodsCD patients who underwent SPECT scans to detect dystonic muscles were included. Candidate muscles were first selected based on clinical evaluation and abnormal radioactivity on SPECT imaging. All patients were injected under the guidance of EMG, and only candidate muscles with positive EMGs were injected. The efficacy of BTX-A was assessed via the subjective clinical improvement rate and the reduction in the Tsui score at four weeks after injection.

resultsThe study enrolled 252 patients. The subjective improvement rates were 63.5%±20.6% for simple types and 59.9%± 22.2% for complex types, and this difference was not significant (p=0.247). The reduction rates of the Tsui score did not differ between the simple type (52.4%±24.2%) and the complex type (49.6%±23.6%, p=0.556). Moreover, clinical improvement rates did not significantly differ within each group of simple subtypes, complex subtypes, or patients with different types of tremors (p>0.05).

conclusionThe efficacy of BTX-A treatment was comparable in different CD patterns because of the appropriate selection of dystonic muscles via SPECT and EMG. Therefore, employing multifaceted approaches to identify dystonic muscles can yield favorable outcomes, even in complex cases.

Indexed as

Botulinum toxinCervical dystoniaCol-Cap classificationElectromyographySPECT

Identifiers

PMID41261363
PMCPMC13175729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.