Evidence map›Paper›PMID 41261310›Full record

ReviewMolecular neurobiology2025

P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives.

Arwa Mithaiwala, Jhanvi Thakur, Angel Godad

Abstract readReview
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In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arwa MithaiwalaDepartment of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy V. L. Mehta Road, Vile Parle (W), V. L. Mehta Road, Mithibai campus, Vile Parle (W), Mumbai, 400056, Maharashtra, India.
Jhanvi ThakurDepartment of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy V. L. Mehta Road, Vile Parle (W), V. L. Mehta Road, Mithibai campus, Vile Parle (W), Mumbai, 400056, Maharashtra, India.
Angel GodadDepartment of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy V. L. Mehta Road, Vile Parle (W), V. L. Mehta Road, Mithibai campus, Vile Parle (W), Mumbai, 400056, Maharashtra, India. angelgodad@gmail.com.ORCID http://orcid.org/0000-0001-8833-8943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purinergic P2X7 (P2RX7) receptor is an ATP-gated ion channel expressed in immune and neuronal cells, with central roles in neuroinflammation, neurodegeneration, and synaptic plasticity. It has been implicated in neurodegenerative, psychiatric, neurodevelopmental, epileptic, and tumor-related disorders, as well as age-associated CNS pathologies. Importantly, P2RX7 functions in a context-dependent manner, displaying both neuroprotective and neurotoxic effects. This review summarizes its molecular structure, genetic polymorphisms, and functional mechanisms, while highlighting its therapeutic relevance across CNS diseases. We also discuss the progress and challenges in developing P2RX7 antagonists, emphasizing their clinical potential in modulating neuroimmune pathways and improving CNS therapeutics.

Indexed as

Central Nervous System DiseasesReceptors, Purinergic P2X7AnimalsHumansPurinergic P2X Receptor AntagonistsPurinergic P2X Receptor AntagonistsReceptors, Purinergic P2X72RX7NeurodegenerationNeuroinflammationP2RX7 antagonismPsychiatric disordersSingle nucleotide polymorphism

Identifiers

PMID41261310

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.