ArticleMolecular neurobiology2025
Anxiolytic-Like Effects of Citronellal and Phytol, Possibly Through the GABAergic Interaction Pathway: In Vivo with Molecular Docking Studies.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
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Abstract
Citronellal (CTL), a natural monoterpenoid aldehyde, and phytol (PHY), a chlorophyll-derived diterpenoid, have been reported to exert neuropharmacological activities with possible GABAergic involvement. This study investigated their anxiolytic-like effects in Swiss albino mice, supported by molecular docking and pharmacokinetic evaluations. Animals received CTL (62.5, 125, and 250 mg/kg, per orally (p.o.)) or PHY (25, 50, and 75 mg/kg, p.o.) either alone or in combination with the gamma-aminobutyric acid (GABA) agonist diazepam (DZP, 2 mg/kg, p.o.) or the GABA antagonist flumazenil (FLU, 0.1 mg/kg, intraperitoneally (i.p.)). Behavioral analyses (open-field, hole-cross, swing, and light-dark tests) revealed that CTL significantly and dose-dependently reduced locomotor activity, while PHY produced variable responses, with higher doses enhancing exploratory behavior. Both compounds potentiated DZP-induced anxiolytic effects and counteracted FLU, suggesting GABAergic modulation. Molecular docking demonstrated stronger binding affinities of PHY (-4.9 and -4.2 kcal/mol) than CTL (-4.7 and -4.0 kcal/mol) at the α2 and α3 subunits of the GABA
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