ArticleMedical oncology (Northwood, London, England)2025
Static magnetic field and alternating magnetic field cytotoxic effects on triple negative breast cancer cell line (MDA-MB-231).
Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Triple-negative breast cancer (TNBC) is described as the most aggressive subtype of breast cancer. TNBC is characterized by the absence of three receptors commonly found in other breast cancer subtypes: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It has a high metastasis capacity, Poor prognosis, and shows a high incidence among young African women with the BRCA1 gene mutation. Thus, TNBC patients are left with limited treatment options. Herein, the magnetic field is chosen as a non-invasive treatment that eliminates the side effects of other conventional therapeutic options. MDA-MB-231 cells were exposed to two types of magnetic fields: a static magnetic field (SMF) and an alternating magnetic field (AMF), with varying intensities and durations. Both SMF and AMF showed cytotoxic effects; cells showed a decrease in viability to percentages up to 58.14 ± 5.51% after exposure to SMF, and 51.17 ± 3.53 % after exposure to AMF, changes in morphological features, changes in populations in cell cycle stages-accumulation in [Formula: see text]/ [Formula: see text] phases and decrease of population in S and [Formula: see text] phases, and a reduction in the total antioxidant capacity of cells to 74.8 ± 0.009 % after exposure to SMF and 89.97 ± 0.006 % after exposure to AMF due to a cytoskeletal disruption. These findings support the use of magnetic fields as a non-invasive alternative to conventional therapies, with further investigation for clinical applications.
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