Evidence map›Paper›PMID 41261285›Full record

ArticleEMBO reports2026

NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity.

Ella Hartenian, Magalie Agustoni, Petr Broz

Abstract read
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. NINJ1: implications for plasma membrane rupture and disease.Biochemical Society transactions · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ella HartenianDepartment of Immunobiology, University of Lausanne, Lausanne, 1066, Switzerland.ORCID http://orcid.org/0000-0001-9277-2152
Magalie AgustoniDepartment of Immunobiology, University of Lausanne, Lausanne, 1066, Switzerland.
Petr BrozDepartment of Immunobiology, University of Lausanne, Lausanne, 1066, Switzerland. petr.broz@unil.ch.ORCID http://orcid.org/0000-0002-2334-7790

Funding

European Molecular Biology Organization (EMBO) ALTF 27-2022Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 310030_219286Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 310030B_192523
6 · The paper itself

Abstract

Restriction factors block multiple stages of viral infection. Here we describe how Ninjurin1 (NINJ1) controls HSV-1 infection of macrophages, a key cell type that protects mice against infection. We observe that Ninj1

Indexed as

Cell Adhesion Molecules, NeuronalHerpes SimplexHerpesvirus 1, HumanMacrophagesVirus InternalizationVirus ReplicationAnimalsCytokinesHumansMiceMice, Inbred C57BLMice, KnockoutNerve Growth FactorsViral LoadCell Adhesion Molecules, NeuronalCytokinesNerve Growth FactorsNinj1 protein, mouseCell DeathHSV-1NINJ1Restriction FactorsVirology

Identifiers

PMID41261285
PMCPMC12796307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.