ArticleAnnals of intensive care2025
End-tidal carbon dioxide changes induced by passive leg raising can predict fluid responsiveness in patients on veno-arterial extracorporeal membrane oxygenation: a prospective, interventional study.
Article in Annals of intensive care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Changes in COJournal of clinical medicine · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVeno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used in patients with cardiogenic shock. It results in cardiopulmonary shunting with reduced native cardiac output. Volume expansion is usually administered to increase native cardiac output, in order to improve peripheric perfusion or to avoid thromboembolic complications in cardiac cavities. End-tidal carbon dioxide (EtCO
methodsIn this prospective, interventional study, patients under VA-ECMO support were included, provided they required volume expansion. The protocol included three sequential steps: (1) Baseline in supine position (2) Passive leg raising (3) Volume expansion in basal position. Hemodynamic parameters were recorded at each step. Fluid responsiveness was defined as a velocity time integral at the left ventricle outflow tract increase of 15% or more after volume expansion. The ability of passive leg raising induced changes in EtCO
results41 patients were studied; 58 passive leg raising - volume expansion tests were recorded. Fluid responsiveness was observed in 38 of the 58 measurements (65%). Passive leg raising test has correctly mimicked volume expansion (intraclass correlation coefficient 0.83 [0.73-0.9]). Considering all measurements, AUC of passive leg raising-changes in velocity time integral to predict fluid responsiveness was 0.89 [0.79-0.99] and remained good whatever the basal native cardiac output. Sensitivity and specificity were 92% [85-100] and 80% [69-90] respectively for a threshold of 15%. AUC of passive leg raising-induced changes in EtCO
conclusionPassive leg raising test can predict fluid responsiveness under VA-ECMO. EtCO
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