Evidence map›Paper›PMID 41261246›Full record

ArticleSurgical endoscopy2026

Prophylactic mucosal defect closure reduces delayed adverse events after endoscopic resection of large-to-giant laterally spreading superficial non-ampullary duodenal epithelial tumors.

Peirong Xu, Ziyu Wang, Zhuo Chen, Zuqiang Liu, Yanfang Tan, Yicheng Tian, Mengjiang He, Quanlin Li, Pinghong Zhou, Hao Hu

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Peirong Xu *Shanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Ziyu Wang *Endoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Zhuo Chen *Department of Gastroenterology, The First People's Hospital of Xuzhou, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu, China.
Zuqiang LiuShanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Yanfang TanShanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Yicheng TianShanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Mengjiang HeShanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Quanlin LiShanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.
Pinghong ZhouShanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China. zhou.pinghong@zs-hospital.sh.cn.ORCID 0000-0002-5434-0540
Hao HuShanghai Collaborative Innovation Center of Endoscopy, Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China. hu.hao1@zs-hospital.sh.cn.

Funding

National Key R&D Program 2022YFC2505100National Key R&D Program 2022YFC2505105National Natural Science Foundation of China 81900548National Natural Science Foundation of China 82370546Science and Technology Commission of Shanghai Municipality 22015831400Science and Technology Commission of Shanghai Municipality 22Y11907500
6 · The paper itself

Abstract

BACKGROUND AND

aimsWe aimed to assess the efficacy of prophylactic mucosal defect closure in reducing delayed adverse events (AEs) after endoscopic resection (ER) of large-to-giant laterally spreading superficial non-ampullary duodenal epithelial tumors (SNADETs). MATERIALS AND

methodsWe performed a retrospective review of 219 patients with 230 large-to-giant laterally spreading SNADETs who underwent ER at Zhongshan Hospital, Fudan University. The preoperative baseline information, procedure-related AEs and follow-up outcomes were compared between lesions with complete closure and those with incomplete closure or no closure.

resultsThe mean maximal diameter was 22.8 ± 13.8 mm (mean ± SD), with 67 lesions (29.1%) ≥ 30 mm. A total of 42 lesions (18.3%) had an occupied circumference ≥ 50%. There were 32 lesions (13.9%) with incomplete closure or non-closure of the mucosal defect. A total of 18 lesions (7.8%) experienced delayed AEs, including delayed perforation in 6 cases (2.6%) and delayed bleeding in 12 cases (5.2%). Lesions with incomplete closure or non-closure had a higher incidence of delayed AEs than lesions with complete closure (34.4% vs 3.5%, P < 0.001). Multivariable regression analyses revealed that incomplete or no mucosal defect closure (OR = 5.154; 95% CI = 1.443-18.405; P = 0.012) and lesions located on the anal side of the major papilla (OR = 11.457; 95% CI = 1.404-93.499; P = 0.023) were independent risk factors for delayed AEs. Lesions with an occupied circumference ≥ 50% (OR = 3.171; 95% CI = 1.024-9.818; P = 0.045) and irregular shape (OR = 5.557; 95% CI = 1.226-25.184; P = 0.026) were independent risk factors for incomplete closure or non-closure.

conclusionsProphylactic mucosal defect closure is an effective technique for reducing delayed AEs after ER of large-to-giant laterally spreading SNADETs.

Indexed as

Duodenal NeoplasmsDuodenoscopyEndoscopic Mucosal ResectionIntestinal MucosaPostoperative ComplicationsWound Closure TechniquesAdultAgedFemaleHumansMaleMiddle AgedPostoperative HemorrhageRetrospective StudiesDelayed bleedingDelayed perforationEndoscopic closureEndoscopic resectionSuperficial non-ampullary duodenal epithelial tumor

Identifiers

PMID41261246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.