Evidence map›Paper›PMID 41261180›Full record

ArticleEuropean radiology2026

CT features of interstitial lung disease in systemic lupus erythematosus and overlap lupus-other connective tissue disease.

Aurore Sajust de Bergues de Escalup, Arthur Mageau, Lou Deneuville, Karim Sacre, Antoine Khalil, Nathalie Costedoat-Chalumeau, Eric Hachulla, Yurdagul Uzunhan, Erwan Le Tallec, Jacques Cadranel and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Aurore Sajust de Bergues de EscalupService de Radiologie, Hôpital Bichat, AP-HP, Paris, France.
Arthur MageauDépartement de Médecine Interne, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
Lou DeneuvilleService de Pneumologie Allergologie et Transplantation, Hôpital Bichat, AP-HP, Paris, France.
Karim SacreDépartement de Médecine Interne, Hôpital Bichat, Assistance Publique Hôpitaux de Paris, Paris, France.
Antoine KhalilUniversité Paris Cité, UMR Inserm 1149, Hôpital Bichat, AP-HP, Service de Radiologie, Paris, France.
Nathalie Costedoat-ChalumeauDépartement de Médecine Interne, Hôpital Cochin, AP-HP, Paris, France.
Eric HachullaCentre de référence des Maladies Auto-Immunes et Auto-inflammatoires Systémiques rares de l'Adulte du Nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM), Service de Médecine Interne et Immunologie Clinique, Hôpital Claude Huriez, Université Lille, Lille, France.
Yurdagul UzunhanService de Pneumologie, Centre constitutif du centre de référence des maladies pulmonaires rares, Hôpital Avicenne, 125 rue de Stalingrad 93000 Bobigny, INSERM U1272, Université Sorbonne Paris Nord, Bobigny, France.
Erwan Le TallecService de Médecine Interne et Immunologie Clinique, CHU de Rennes, Rennes, France.
Jacques CadranelService de Pneumologie et Oncologie thoracique, Centre constitutif du Centre de Référence Maladies Pulmonaires rares, Hôpital Tenon AP-HP, Paris, France.
Sylvain Marchand-AdamService de Pneumologie et explorations fonctionnelles respiratoires, CHRU de Tours, Inserm, Tours, France.
David MontaniDepartment of Respiratory and Intensive Care Medicine (FHU André Cournand, ERN-LUNG), Hôpital Bicêtre (AP-HP), Université Paris-Saclay, Inserm UMR_S 999 (HPPIT), Le Kremlin Bicêtre, France.
Martine Reynaud-GaubertDepartment of Respiratory Medicine, AP-HM, Hôpital Nord, Aix Marseille Université, C2VN-INSERM1263-INRAE1260, Marseille, France.
Grégoire PrévotService de Pneumologie, CHU Toulouse, Toulouse, France.
Guillaume BeltramoCentre de référence constitutif des maladies pulmonaires rares de l'adultes, Inserm 1231 CTM, Université Bourgogne Europe, Centre Hospitalo-Universitaire Dijon-Bourgogne, Institut Universitaire du Poumon, Dijon, France.
Bruno CrestaniUniversité Paris Cité, UMR Inserm 1149, CRI, Hôpital Bichat, AP-HP, Service de Pneumologie Allergologie et Transplantation, FHU INFIRE, Paris, France.
Vincent CottinService de Pneumologie, Centre coordonnateur national de référence des maladies pulmonaires rares, Hôpital Louis Pradel,59 boulevard Pinel 69500 Bron, Université Claude Bernard Lyon 1, Université de Lyon; INRAE; ERN-LUNG, Lyon, France.
Raphaël BorieUniversité Paris Cité, UMR Inserm 1149, CRI, Hôpital Bichat, AP-HP, Service de Pneumologie Allergologie et Transplantation, FHU INFIRE, Paris, France.
Marie-Pierre DebrayUniversité Paris Cité, UMR Inserm 1149, Hôpital Bichat, AP-HP, Service de Radiologie, FHU INFIRE, Paris, France. marie-pierre.debray@aphp.fr.ORCID http://orcid.org/0000-0003-2109-5662
OrphaLung Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo describe initial and follow-up CT features of chronic interstitial lung disease (cILD) associated with systemic lupus erythematosus (SLE), focusing on variant signs of lung fibrosis. MATERIALS AND

methodsThis multicentric retrospective study included 76 patients (72 females, 95%, median age: 46 years) with both cILD and SLE, including 46 patients having another connective tissue disease (CTD) associated with lupus. Two radiologists independently reviewed chest CTs for ILD pattern and variant fibrosis signs. Radiologic progression of ILD was analyzed in 52 patients. Pulmonary function tests were collected at baseline and follow-up if available. Data were analyzed using Fisher's exact and Wilcoxon's rank sum tests. Inter-reader agreement was assessed using Cohen's Kappa coefficients.

resultsThe most frequent ILD patterns were non-specific interstitial pneumonia (NSIP) in 31/76 (41%) patients, among which 5 showed overlap organizing pneumonia features, indeterminate in 18/76 (24%) patients, and usual interstitial pneumonia in 10/76 (13%) patients. The overall inter-reader agreement for the CT pattern was moderate (κ = 0.52). Any variant sign of fibrosis, including anterior-upper-lobe sign, exuberant-honeycombing, island-like fibrosis, and straight-edge sign, was observed in 14/76 (18%) patients, with an overall inter-reader agreement of 0.62, highly variable according to the sign considered. After 100 months of median follow-up, CT showed signs of progressive ILD in 36/52 (69%) patients, with poor correlation between functional and radiological progression.

conclusionSLE-associated cILD most often showed an NSIP or indeterminate pattern, commonly associated with variant signs of lung fibrosis. After a median follow-up of 100 months, 69% of patients showed CT signs of progression. KEY POINTS: Question Radiologic presentation and progression of cILD in SLE remain poorly defined, limiting the ability to guide long-term clinical management. Findings NSIP (more common in isolated lupus) and indeterminate patterns predominated, with variant fibrosis signs of variable reproducibility. Two-thirds of patients showed progressive ILD. Clinical relevance CT helps characterize and monitor lupus-associated interstitial lung disease, but limited pattern reproducibility and weak correlation with functional decline support the need for multidisciplinary evaluation and individualized follow-up strategies.

Indexed as

Connective Tissue DiseasesLung Diseases, InterstitialLupus Erythematosus, SystemicTomography, X-Ray ComputedAdultAgedDisease ProgressionFemaleHumansLungMaleMiddle AgedRespiratory Function TestsRetrospective StudiesComputed tomographyConnective tissue diseaseFibrosis variantsInterstitial lung diseaseSystemic lupus erythematosus

Identifiers

PMID41261180

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.