Evidence map›Paper›PMID 41261129›Full record

ArticleNature2026

Hepatic zonation determines tumorigenic potential of mutant β-catenin.

Alexander Raven, Kathryn Gilroy, Hu Jin, Joseph A Waldron, Holly Leslie, June Munro, Holly Hall, Rachel A Ridgway, Catriona A Ford, Doga C Gulhan and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Alexander RavenCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-4409-9543
Kathryn GilroyCancer Research UK Scotland Institute, Glasgow, UK.
Hu JinDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8657-5686
Joseph A WaldronCancer Research UK Scotland Institute, Glasgow, UK.
Holly LeslieSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
June MunroCancer Research UK Scotland Institute, Glasgow, UK.
Holly HallCancer Research UK Scotland Institute, Glasgow, UK.
Rachel A RidgwayCancer Research UK Scotland Institute, Glasgow, UK.
Catriona A FordCancer Research UK Scotland Institute, Glasgow, UK.
Doga C GulhanDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Nikola VlahovCancer Research UK Scotland Institute, Glasgow, UK.
Megan L MillsCancer Research UK Scotland Institute, Glasgow, UK.
Andrew HartleyCancer Research UK Scotland Institute, Glasgow, UK.
Eve AndersonCancer Research UK Scotland Institute, Glasgow, UK.
Sheila BrysonCancer Research UK Scotland Institute, Glasgow, UK.
Nathalie SphyrisCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-1860-1958
Miryam MüllerCancer Research UK Scotland Institute, Glasgow, UK.
Stephanie MayCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-0095-7403
Barbara CaddenCancer Research UK Scotland Institute, Glasgow, UK.
Colin NixonCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-8085-2160
Scott H WaddellMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Rachel GuestMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Luke BoulterMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-7954-6705
Nick BarkerInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.ORCID 0000-0003-3566-4475
Hans CleversPharma, Research and Early Development (pRED) of F. Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0002-3077-5582
Hao ZhuChildren's Research Institute and Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8417-9698
Johanna IvaskaTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.ORCID 0000-0002-6802-6739
Douglas StrathdeeCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-2959-4327
Crispin J MillerCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0003-4341-1283
Nigel B JamiesonSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-9552-4725
Martin BushellCancer Research UK Scotland Institute, Glasgow, UK.
Peter J ParkDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9378-960X
Thomas G BirdCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0002-6120-1581
Owen J SansomCancer Research UK Scotland Institute, Glasgow, UK. o.sansom@crukscotlandinstitute.ac.uk.ORCID 0000-0001-9540-3010

Funding

Determining how chronic ETOH influences the regenerative activities of hepatocyte subpopulationsR01AA028791 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2021 to 2025
$2.7M
Improving hepatocellular carcinoma mouse modeling by understanding the malignant potential and biology of liver cell subpopulationsR01CA251928 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHU, HAO · 2020 to 2024
$2.7M
NCI NIH HHS R01 CA251928NIAAA NIH HHS R01 AA028791Wellcome Trust
6 · The paper itself

Abstract

Oncogenic mutations in phenotypically normal tissue are common across adult organs

Indexed as

beta CateninCarcinogenesisLiverLiver NeoplasmsMutant ProteinsMutationAllelesAnimalsCarcinoma, HepatocellularCell DifferentiationCell ProliferationCyclin D1FemaleHepatocytesHumansMalebeta CateninCTNNB1 protein, mouseCyclin D1mTOR protein, mouseMutant ProteinsMyc protein, mouseProto-Oncogene Proteins c-mycTOR Serine-Threonine Kinases

Identifiers

PMID41261129
PMCPMC12804091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.