Evidence map›Paper›PMID 41261126›Full record

ArticleNature2026

Structural basis of regulated N-glycosylation at the secretory translocon.

Melvin Yamsek, Mengxiao Ma, Roshan Jha, Yu Wan, Qianru Li, Frank Zhong, Katherine DeLong, Zhe Ji, Rajat Rohatgi, Robert J Keenan

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Melvin Yamsek *Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.
Mengxiao Ma *Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
Roshan Jha *Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA.ORCID 0000-0002-6332-9968
Yu WanDepartment of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA.ORCID 0009-0004-9016-2376
Qianru LiDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Frank ZhongDepartment of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL, USA.
Katherine DeLongDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0008-7269-778X
Zhe JiDepartment of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0002-1809-8099
Rajat RohatgiDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA. rrohatgi@stanford.edu.ORCID 0000-0001-7609-8858
Robert J KeenanDepartment of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL, USA. bkeenan@uchicago.edu.ORCID 0000-0003-1466-0889

Funding

Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
Supplement application for an Olympus automated microscopeR35GM118082 · NIGMS · STANFORD UNIVERSITY · PI RAJAT ROHATGI · 2016 to 2026
$7.6M
Membrane protein biogenesis at the ERR35GM145374 · NIGMS · UNIVERSITY OF CHICAGO · PI Robert J Keenan · 2022 to 2026
$3.5M
Characterizing functional translation in putative 'noncoding' regions of a genome: Admin SupplR35GM138192 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JI, ZHE · 2020 to 2024
$2.1M
Beagle-3: A Shared GPU Cluster for Biomolecular SciencesS10OD028655 · OD · UNIVERSITY OF CHICAGO · PI ROUX, BENOIT · 2020 to 2020
$2.0M
An ultra-low-input RNase footprinting assay to quantify cytosolic and mitochondrial translation simultaneouslyR01HL161389 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI JI, ZHE · 2022 to 2025
$1.9M
A molecular pathway that links N-glycosylation to birth defectsR01HD113790 · NICHD · STANFORD UNIVERSITY · PI RAJAT ROHATGI · 2024 to 2026
$996k
NHLBI NIH HHS R01 HL161389NICHD NIH HHS R01 HD113790NIGMS NIH HHS R35 GM118082NIGMS NIH HHS R35 GM138192NIGMS NIH HHS R35 GM145374NIGMS NIH HHS T32 GM007183NIH HHS S10 OD028655
6 · The paper itself

Abstract

Most human secretory pathway proteins are N-glycosylated by oligosaccharyltransferase (OST) complexes as they enter the endoplasmic reticulum (ER)

Indexed as

HSP70 Heat-Shock ProteinsMembrane GlycoproteinsMembrane ProteinsSecretory PathwayEndoplasmic ReticulumGlycosylationHexosyltransferasesHumansHydrophobic and Hydrophilic InteractionsModels, MolecularProtein Foldingdolichyl-diphosphooligosaccharide - protein glycotransferaseHexosyltransferasesHSP70 Heat-Shock ProteinsMembrane GlycoproteinsMembrane Proteins

Identifiers

PMID41261126
PMCPMC12804085

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.