Evidence map›Paper›PMID 41261106›Full record

ArticleNature communications2025

Bench-stable reagents for modular access to persulfuranyl scaffolds.

Renzhe Li, Chang Liu, Chao Hu, Jet Tsien, Michael Hayes, Si-Jie Chen, Yuzuru Kanda, Rohan R Merchant, Bryan S Matsuura, Tian Qin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Visible Light-Driven Copper-Catalyzed Asymmetric Synthesis via Sequential C(spAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals.Journal of the American Chemical Society · 2026
    Article
  4. Article
  5. Article
  6. Modular Access toJournal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Renzhe LiDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chang LiuDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-7100-9983
Chao HuDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jet TsienDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
Michael HayesDepartment of Discovery Chemistry, Merck & Co., Inc., South San Francisco, CA, USA.
Si-Jie ChenDepartment of Discovery Chemistry, Merck & Co., Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9836-6892
Yuzuru KandaNovartis Biomedical Research, Cambridge, MA, USA.
Rohan R MerchantDepartment of Discovery Chemistry, Merck & Co., Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5472-8780
Bryan S MatsuuraDepartment of Discovery Chemistry, Merck & Co., Inc., South San Francisco, CA, USA.
Tian QinDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA. tian.qin@utsouthwestern.edu.ORCID http://orcid.org/0000-0001-7225-3224

Funding

Development of Sulfur-Based Reactions with Translational ApplicationsR01GM141088 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Tian Qin · 2021 to 2026
$2.1M
NIGMS NIH HHS R01 GM141088Welch Foundation I-2155-20230405
6 · The paper itself

Abstract

Pentafluorosulfanyl group has been long considered a potential (bio)isostere for tert-butyl and trifluoromethyl groups, yet limitations in methodologies have constrained access to it. To bridge this gap, we have developed a general pentafluorosulfanylation platform that employs bench-stable solid reagents to generate SF

Identifiers

PMID41261106
PMCPMC12630828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.