ArticleMedical physics2025
Efficient estimation of gadolinium-based contrast agent concentration using transient-state keyhole MR-STAT.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Efficient estimation of gadolinium-based contrast agent concentration using transient-state keyhole MR-STAT.Medical physics · 2025Article
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8 authors.
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Abstract
backgroundFast quantitative MRI (qMRI) techniques have emerged to quantify multiple tissue parameters from a single acquisition in clinically feasible scan times. To integrate fast qMRI techniques into a clinical MRI protocol, one needs to consider imaging after injection of a contrast agent (e.g., dynamic contrast-enhanced [DCE] imaging). However, fully repeating the multi-parametric scan after the injection requires lengthy scan times, which are impractical for tracking the contrast agent concentration. PURPOSE: This work aimed to develop and validate an accelerated multi-parametric method capable of estimating the concentration of Gadolinium-based contrast agents (GBCAs) in a more time-efficient way.
methodsWe designed an accelerated 2D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) protocol and tested it on a 3T MRI scanner. This is achieved by combining transient-state acquisitions with Cartesian keyhole-based acceleration. Based on the reconstructed T
resultsThe accelerated MR-STAT protocol, with an undersampling factor of 4, provided accurate T
conclusionWe present a multi-parametric approach for quantitatively assessing the concentration of gadolinium in vitro and in a hybrid in vivo/in vitro controlled setup using the accelerated MR-STAT protocol. The concentration of gadobutrol in the range of 0.05-0.9 mM could be measured in a clinically applicable scan time using the proposed method, but needs further in vivo validation.
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