Evidence map›Paper›PMID 41261047›Full record

ArticleObesity (Silver Spring, Md.)2026

Association of a Lifestyle Risk Index With Visceral and Subcutaneous Adipose Tissue in the German National Cohort (NAKO).

Gertraud Maskarinec, Rebecca Klapp, Ute Nöthlings, Matthias B Schulze, Fabian Bamberg, Jürgen Machann, Sabrina Schlesinger, Michael Leitzmann, Anja Sedlmeier, Patricia Bohmann and 38 more

Abstract read
In one paragraph

Article in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Gertraud MaskarinecUniversity of Hawaii Cancer Center, Honolulu, Hawaii, USA.ORCID https://orcid.org/0000-0002-8129-958X
Rebecca KlappMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0009-0006-6057-1050
Ute NöthlingsInstitute of Nutritional and Food Sciences-Nutritional Epidemiology, University of Bonn, Bonn, Germany.
Matthias B SchulzeGerman Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
Fabian BambergDepartment of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jürgen MachannInstitute for Diabetes Research and Metabolic Diseases, Helmholtz Munich at the University of Tübingen, Tübingen, Germany.
Sabrina SchlesingerInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University, Düsseldorf, Germany.
Michael LeitzmannInstitute for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Anja SedlmeierInstitute for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Patricia BohmannInstitute for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Susanne RospleszczDepartment of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-4788-2341
Johanna NattenmüllerDepartment of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Tobias HaueiseInstitute for Diabetes Research and Metabolic Diseases, Helmholtz Munich at the University of Tübingen, Tübingen, Germany.
Karen SteindorfDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thoralf NiendorfMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Christopher L SchlettDepartment of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Karin Halina GreiserDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Leo PanreckNAKO e.V., Heidelberg, Germany.
Jakob LinseisenEpidemiology, Medical Faculty, University of Augsburg, Augsburg, Germany.
Christina-Alexandra ConzenInstitute of Nutritional and Food Sciences-Nutritional Epidemiology, University of Bonn, Bonn, Germany.
Sylvia GastellGerman Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
Tamara SchikowskiIUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Robin BülowInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Fiona NiedermayerInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Heiko BecherInstitute for Global Health, University Hospital Heidelberg, Heidelberg, Germany.
André KarchInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ute MonsDivision of Primary Cancer Prevention, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0003-1764-6783
Boerge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Andreas StangInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Rafael MikolajczykInstitute for Medical Epidemiology, Biometrics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Alexander KluttigInstitute for Medical Epidemiology, Biometrics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Wolfgang LiebInstitute of Epidemiology, Kiel University, Kiel, Germany.
Cara ÖvermöhleInstitute of Epidemiology, Kiel University, Kiel, Germany.
Antje HebestreitLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Kathrin GüntherLeibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Volker HarthInstitute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nadia ObiInstitute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefanie CastellDepartment for Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Lower Saxony, Germany.
Robyn KettlitzDepartment for Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Lower Saxony, Germany.
Katharina NimptschMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Tobias PischonMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID https://orcid.org/0000-0003-1568-767X

Funding

Federal Ministry of Education and Research 01ER1301A/B/CFederal Ministry of Education and Research 01ER1511DFederal Ministry of Education and Research 01ER1801A/B/C/DFederal Ministry of Education and Research 01ER2301A/B/CHelmholtz AssociationLeibniz AssociationStiftung Charité
6 · The paper itself

Abstract

objectiveThis cross-sectional study examined a Lifestyle Risk Factor Index (LSRI) in relation to adiposity measures including visceral adipose tissue (VAT) in the German National Cohort (NAKO).

methodsBased on self-reports at baseline among 30,920 of > 205,000 NAKO eligible participants with magnetic resonance imaging (MRI) scans, one point each for not smoking, adhering to ≥ 3/7 diet recommendations, consuming ≤ 1 (women)/≤ 2 (men) alcoholic drinks/day, and ≥ 150 min/week physical activity was assigned. VAT volume, obtained from whole-body MRI at 3T, was analyzed by deep learning-based image segmentation. General linear models estimated adjusted geometric mean adiposity measures by LSRI and stratified analyses by sex and BMI.

resultsOf 18,508 participants aged 48.2 ± 12.2 years, the respective proportions for 0/1, 2, 3, and 4 LSRI points were 7%, 24%, 51%, and 18%. Participants with LSRI scores of 4 versus 0/1 had lower adjusted geometric mean volumes of VAT (2.3; 95% CI 2.2, 2.3 vs. 3.0; 95% CI 2.9, 3.1 L). These differences were slightly attenuated after adding BMI. This association was weaker for individuals with obesity than normal/overweight.

conclusionA combination of lifestyle factors appears to be associated with lower VAT volume, but an elevated BMI may have a greater influence on VAT accumulation than lifestyle behaviors alone.

Indexed as

Intra-Abdominal FatLife StyleSubcutaneous FatAdiposityAdultBody Mass IndexCohort StudiesCross-Sectional StudiesExerciseFemaleGermanyHumansMagnetic Resonance ImagingMaleMiddle AgedObesitybody fat distributioncohort studylifestyle behaviorsobesity

Identifiers

PMID41261047
PMCPMC12724031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.