Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Yunzhan NingDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.ORCID 0000-0001-6879-786X
Nina-Louisa EfrémDepartment of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, Berlin 13125, Germany.
Machoud AmoussaDepartment of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, Berlin 13125, Germany.
Ertan TurhanInstitute of Biological Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria.
Dazhong ZhengInstitute of Food Chemistry, Leibniz University Hannover, Callinstraße 5, Hannover 30167, Germany.
Jonathan LefèbreDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.ORCID 0000-0001-8505-2181
Max RuwoltInstitute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Takustr. 6, Berlin 14195, Germany.ORCID 0009-0000-7220-406X
Ursula NeuInstitute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Takustr. 6, Berlin 14195, Germany.
Maurice BeschDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.ORCID 0000-0001-9242-0261
Bernhard LollInstitute of Chemistry and Biochemistry, Laboratory of Structural Biochemistry, Freie Universität Berlin, Takustr. 6, Berlin 14195, Germany.ORCID 0000-0001-7928-4488
Dennis KurzbachInstitute of Biological Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria.ORCID 0000-0001-6455-2136
Jesko KöhnkeInstitute of Food Chemistry, Leibniz University Hannover, Callinstraße 5, Hannover 30167, Germany.
Marc NazaréDepartment of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, Berlin 13125, Germany.ORCID 0000-0002-1602-2330
Christoph RademacherDepartment of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, Vienna 1090, Austria.ORCID 0000-0001-7082-7239
Funding
Austrian Science Fund FWF I 5157Austrian Science Fund FWF I 5771
6 · The paper itself
Abstract
C-Type lectins are a large family of carbohydrate-binding proteins. Langerin is a member of this family and is expressed by Langerhans cells, involved in pathogen recognition and innate immune activation, making it a target for small-molecule modulation in immunology and infectious diseases. We previously identified thiazolopyrimidinones as a series of allosteric inhibitors, but the underlying mechanism remained unclear. In this study,
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. · full record | OpenQuestion