Evidence map›Paper›PMID 41260927›Full record

Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2026

Combined Psychoeducational and Exercise Training Intervention to Improve Mental Health and Physical Functioning in Late-Life: A Randomized Controlled Trial.

Margarita Alegria, Walter Frontera, Mario Cruz-Gonzalez, Sheri Markle, Aida Jimenez, Zorangeli Ramos, Taysha Bruno-Ortiz, Larimar Fuentes, Megan Cheung, Yankau Josephine Wong and 2 more

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Benefit and Uptake: A Mixed Methods Study Exploring Older Adults' Experiences With a Psychoeducational and Exercise Training Maintenance Intervention.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Margarita AlegriaDisparities Research Unit, Department of Medicine (MA, MCG, SM, ZR, TBO, LF, YJW), Massachusetts General Hospital, Boston, MA; Department of Medicine (MA, MCG), Harvard Medical School, Boston, MA; Department of Psychiatry (MA), Harvard Medical School, Boston, MA. Electronic address: malegria@mgh.harvard.edu.
Walter FronteraDepartment of Physical Medicine (WF), Rehabilitation and Sports Medicine and Physiology and Biophysics, University of Puerto Rico, Río Piedras, Puerto Rico.
Mario Cruz-GonzalezDisparities Research Unit, Department of Medicine (MA, MCG, SM, ZR, TBO, LF, YJW), Massachusetts General Hospital, Boston, MA; Department of Medicine (MA, MCG), Harvard Medical School, Boston, MA.
Sheri MarkleDisparities Research Unit, Department of Medicine (MA, MCG, SM, ZR, TBO, LF, YJW), Massachusetts General Hospital, Boston, MA.
Aida JimenezDepartment of Psychology (AJ), University of Puerto Rico, San Juan, Puerto Rico.
Zorangeli RamosDisparities Research Unit, Department of Medicine (MA, MCG, SM, ZR, TBO, LF, YJW), Massachusetts General Hospital, Boston, MA.
Taysha Bruno-OrtizDisparities Research Unit, Department of Medicine (MA, MCG, SM, ZR, TBO, LF, YJW), Massachusetts General Hospital, Boston, MA.
Larimar FuentesDisparities Research Unit, Department of Medicine (MA, MCG, SM, ZR, TBO, LF, YJW), Massachusetts General Hospital, Boston, MA.
Megan CheungGreater Boston Chinese Golden Age Center (MC), Boston, MA.
Yankau Josephine WongDisparities Research Unit, Department of Medicine (MA, MCG, SM, ZR, TBO, LF, YJW), Massachusetts General Hospital, Boston, MA.
Irene Falgas-BagueDepartment of Epidemiology & Public Health (IFB), Swiss Tropical and Public Health Institute, Basel, Switzerland; Department of Clinical Research, University of Basel (IFB), Basel, Switzerland.
Patrick E ShroutDepartment of Psychology (PES), New York University, New York, NY.

Funding

Building Community Capacity for Disability Prevention for Minority Elders Diversity Supplement IIR01AG046149 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI ALEGRIA, MARGARITA · 2014 to 2024
$9.4M
NIA NIH HHS R01 AG046149
6 · The paper itself

Abstract

objectiveTo assess the effectiveness of an enhanced psychoeducational and exercise training intervention (Positive Minds Strong Bodies-Enhanced [PMSB-E]) on depression and anxiety symptoms and physical functioning.

designRandomized trial of 427 participants, assigned to intervention or usual care.

setting51 community-based organizations and 17 clinics in Massachusetts, New York, Puerto Rico, and Maryland, US. Data collected from November 2020 to October 2024, at baseline and months 3, 6, and 12.

participantsAdults aged 60+ or older with mild to severe depression or anxiety symptoms, minor to moderate mobility limitations, and fluency in English, Spanish, Mandarin, or Cantonese.

interventionsTen psychoeducational and 36 exercise sessions over 6 months compared to usual care (one-on-one phase; 1:1 ratio). Half of the intervention participants were offered an additional 6-month group maintenance phase (1:1 ratio). Control participants received up to 4 usual care calls. MEASUREMENTS: Primary outcome was change from baseline to month 12 in depression and anxiety symptoms (Hopkins Symptom Checklist-25 [HSCL-25]) and physical functioning (Short Physical Performance Battery [SPPB] and Late-Life Functioning and Disability Instrument [LLFDI]). Secondary outcome was change in month 6.

resultsIntervention participants showed improved SPPB scores in month 12 (standardized difference, 0.28; 95% CI, 0.07-0.49) and month 6 (0.34; 95% CI, 0.14-0.55). There were no effects on LLFDI or HSCL-25 scores, nor interaction effects by race and ethnicity. Completing the recommended number of sessions had a larger effect on SPPB scores.

conclusionsPMSB-E replicated previous findings of improving objective physical functioning but not self-reported physical functioning or mental health symptoms. We believe this is due to virtual administration during the pandemic.

Indexed as

AnxietyDepressionExercise TherapyMental HealthPatient Education as TopicPhysical Functional PerformanceAgedAged, 80 and overFemaleHumansMaleMiddle Agedcommunity health workerscultural adaptationHealth disparitiesintervention

Identifiers

PMID41260927
PMCPMC12643175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.