ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
The Highly Localized Interaction between Neurofascin-186 and Gliomedin Promotes Subcellular Innervation by the Chandelier Cell.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A variety of cortical inhibitory interneuron (IN) subtypes differentially but coordinately operate in local circuits to process neuronal signals. The subcellular arrangement of IN synaptic outputs contributes to subtype-specific functional specialization. However, it remains poorly understood what intercellular molecular interactions enable the matched synapse formation between IN subtypes and specific subcellular domains. Using mice of both sexes, we demonstrate that Neurofascin-186 (NF186), a cell adhesion molecule specifically expressed in the axon initial segments (AISs) of pyramidal neurons, is necessary for chandelier cells (ChCs) to develop a string of synaptic boutons along the AIS (an axon cartridge). Furthermore, we discovered that Gliomedin, a known receptor for NF186 in the nodes of Ranvier, is preferentially expressed in ChCs and mediates ChC axon cartridge development by acting as a major receptor for NF186. Thus, the intercellular interaction through subcellularly restricted ligands and cell type-specific receptors ensures a high degree of IN subcellular synapse specificity.
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