Evidence map›Paper›PMID 41260761›Full record

ReviewGastrointestinal endoscopy clinics of North America2026

Pathogenesis of Barrett's Esophagus: Evolving and Emerging Mechanisms.

Omar Martinez-Uribe, Thomas C Becker, Katherine S Garman

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastrointestinal endoscopy clinics of North America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Omar Martinez-UribeDivision of Gastroenterology, Department of Medicine, Duke University, DUMC 3913, Durham, NC 27710.
Thomas C BeckerDivision of Endocrinology, Department of Medicine, Duke University, DUMC 3913, Durham, NC 27710.
Katherine S GarmanDivision of Gastroenterology, Department of Medicine, Duke University, DUMC 3913, Durham, NC 27710. Electronic address: Katherine.Garman@duke.edu.

Funding

Pathways of Injury and Repair in Barrett's CarcinogenesisP01CA269019 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK, Kishore Guda · 2023 to 2026
$11.1M
DUKE TRAINING GRANT IN DIGESTIVE DISEASES AND NUTRITIONT32DK007568 · NIDDK · DUKE UNIVERSITY · PI Katherine Garman, Rodger A. Liddle · 1988 to 2026
$5.6M
The role of gastrin in esophageal submucosal gland acinar ductal metaplasiaR01DK118022 · NIDDK · DUKE UNIVERSITY · PI GARMAN, KATHERINE · 2018 to 2022
$2.3M
NCI NIH HHS P01 CA269019NIDDK NIH HHS R01 DK118022NIDDK NIH HHS T32 DK007568
6 · The paper itself

Abstract

This article seeks to provide updated information on the pathogenesis of Barrett's esophagus (BE) including the possible cellular origins of esophageal columnar cells and the impact of chronic esophageal inflammation. Other considerations include clinical exposures and the importance of risk factor modifications such as weight loss and tobacco cessation. The article summarizes genetic risk factors in the pathogenesis of BE and discusses how familial risk and exposures are considered in current guidelines to identify those who may benefit from BE screening. Finally, insights gleaned from postablative therapy are integrated into this article for both clinical providers and researchers.

Indexed as

Barrett EsophagusEsophageal NeoplasmsEsophagusGenetic Predisposition to DiseaseHumansRisk FactorsAblative therapyBarrett’s esophagusCellular originsGenetic riskInflammationPathogenesisScreening

Identifiers

PMID41260761
PMCPMC13307132

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.