Evidence map›Paper›PMID 41260710›Full record

ReviewCritical care clinics2026

Cardiac Arrest Pharmacopeia: A Personalized Approach to Drug Administration During Cardiopulmonary Resuscitation.

Catherine E Ross, John H Lee, Morgann Loaec, Santiago O Valdés, Michael W Donnino, Robert A Berg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care clinics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Catherine E RossDepartment of Pediatrics, Boston Children's Hospital, Medical Critical Care Offices, 333 Longwood Avenue, Boston, MA 02115, USA. Electronic address: Catherine.Ross@childrens.harvard.edu.
John H LeeDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, RB108B7, Boston, MA 02215, USA.
Morgann LoaecDepartment of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Office 9NW29, Philadelphia, PA 19104, USA.
Santiago O ValdésDepartment of Pediatrics, Lillie Frank Abercrombie Division of Pediatric Cardiology, Baylor College of Medicine, Texas Children's Hospital, 6651 Main Street, Suite E1920, Houston, TX 77030, USA.
Michael W DonninoDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, RB108B7, Boston, MA 02215, USA; Department of Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road, RB108B7, Boston, MA 02215, USA.
Robert A BergDepartment of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Division of Critical Care Medicine, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Office 9NW29, Philadelphia, PA 19104, USA.

Funding

Training Program in Resuscitation ScienceT32HL155020 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Michael William Donnino, Robert Yeh · 2021 to 2026
$2.6M
Thaimine as an adjunct metabolic resuscitator in cardiac arrestK24HL127101 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DONNINO, MICHAEL WILLIAM · 2015 to 2024
$1.2M
Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect TrialK23HL148312 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ROSS, CATHERINE · 2020 to 2024
$1.0M
NHLBI NIH HHS K23 HL148312NHLBI NIH HHS K24 HL127101NHLBI NIH HHS T32 HL155020
6 · The paper itself

Abstract

In this article, we describe the potential for personalized cardiopulmonary resuscitation using physiology to guide drug administration. We also highlight the limitations of the current evidence to inform a more individualized approach. Several areas for possible modifications to drug management are ripe for investigation, including: vasopressor selection and titration based on diastolic blood pressure responses; special physiologic circumstances in which sodium bicarbonate or calcium may be beneficial; and certain electrophysiologic states in shockable cardiac arrest, which may favor lidocaine or amiodarone.

Indexed as

Cardiopulmonary ResuscitationHeart ArrestPrecision MedicineAnti-Arrhythmia AgentsHumansLidocaineVasoconstrictor AgentsAnti-Arrhythmia AgentsLidocaineVasoconstrictor AgentsAmiodaroneCalciumCardiac arrestEpinephrineLidocaineSodium bicarbonateVasopressin

Identifiers

PMID41260710
PMCPMC13487660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.