Evidence map›Paper›PMID 41260542›Full record

ReviewPharmacology & therapeutics2026

Cell phenotypic conversion and fate change during the host defense response, tissue injury and repair.

Xin Shi, Gabriel Mekis, Kevin J Simms, Bin Gao, Ping Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pharmacology & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xin ShiDepartment of Biomedical Sciences, Department of Surgery, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Gabriel MekisDepartment of Biomedical Sciences, Department of Surgery, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Kevin J SimmsDepartment of Biomedical Sciences, Department of Surgery, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Bin GaoLaboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Ping ZhangDepartment of Biomedical Sciences, Department of Surgery, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA. Electronic address: pzhang@neomed.edu.

Funding

Sca-1 signaling, EPC, and the inflammatory response to septic infectionR01GM132449 · NIGMS · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, PING · 2019 to 2022
$1.4M
Alcohol impairs the HSPC response to septic infectionR21AA031725 · NIAAA · NORTHEAST OHIO MEDICAL UNIVERSITY · PI ZHANG, PING · 2024 to 2025
$410k
NIAAA NIH HHS R21 AA031725NIGMS NIH HHS R01 GM132449
6 · The paper itself

Abstract

In the process of host response to insults of serious injury/intense stressor, many types of somatic cells can undergo phenotypic conversion and fate change. The typical feature of cell conversion in this circumstance is to acquire the status of upstream precursors, which commonly accompanies transcriptional alteration to enhance cell proliferation and increase the plasticity of differentiation toward the lineage(s) needed in urgency for defending host against injury as well as maintaining/restoring the integrity of organ tissue function. The extent of cell conversion varies dependent on cell types and insult properties. Pattern ligands derived from pathogens and damaged tissues as well as the dynamic changes in systemic neurohumoral environment and local niche cue mediate cell conversion. Distinctive signaling interplays are involved in regulating various types of cell conversion. Better understanding the phenomena of cell conversion and their underlying regulatory mechanisms is critical for advancing regenerative medicine and developing novel therapeutic strategies to promote host defense as well as optimal repair of organ tissue injury. This article reviews recent progress in investigation on cell conversion and state change in different organ tissue environments with focus on bone marrow, vascular endothelium, lung, liver, and intestine. Discussion on delineating the signaling mechanisms is extended. Efforts in exploring the correlated therapeutic approaches are addressed to highlight the substantial potential in clinical application for this field of regenerative medicine.

Indexed as

Wound HealingAnimalsCell DifferentiationHumansPhenotypeSignal TransductionCell signalingDirect reprogrammingFate changeHost defense responsePhenotypic conversionStem/progenitorTissue injury repair

Identifiers

PMID41260542
PMCPMC12687908

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.