Evidence map›Paper›PMID 41260206›Full record

ArticleCell reports. Medicine2025

Virus envelope glycoprotein targeting bispecific T cell engager protects mice from lethal severe fever with thrombocytopenia virus infection.

Xuefang Peng, Wei Wang, Yuexia Liang, Yi Jian, Qiaoyue Wei, Tong Yang, Chaojie Wang, Xiaohong Yin, Mingjuan Du, Hang Shang and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Xuefang PengState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
Wei WangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Yuexia LiangState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China; CNBG-Nankai University Joint Research and Development Center, Beijing Institute of Biological Products, Beijing 100176, China.
Yi JianState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China.
Qiaoyue WeiSchool of Public Health, Wuhan University, Wuhan, Hubei 430071, China.
Tong YangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.
Chaojie WangState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.
Xiaohong YinState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.
Mingjuan DuShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.
Hang ShangState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China.
Ruobing LiuSchool of Public Health, Wuhan University, Wuhan, Hubei 430071, China.
Xi WangSchool of Public Health, Anhui Medical University, Hefei 230022, China.
Xing ShangSchool of Public Health, Anhui Medical University, Hefei 230022, China.
Nanxin GongState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China.
Yanqin XuState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China.
Chunlei WangState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China.
Ning CuiThe 154(th) Hospital, Xinyang, Henan 464000, China.
Leike ZhangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
Yu GuoState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China.
Wei LiuState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China.
Hongkai ZhangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin 300071, China; CNBG-Nankai University Joint Research and Development Center, Beijing Institute of Biological Products, Beijing 100176, China. Electronic address: hongkai@nankai.edu.cn.
Hao LiState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing 100071, China; School of Public Health, Wuhan University, Wuhan, Hubei 430071, China; School of Public Health, Anhui Medical University, Hefei 230022, China. Electronic address: lihao_1986@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever disease caused by the SFTS virus (SFTSV). Despite pandemic concerns arising from repeated instances of human-to-human transmission and a high fatality rate, effective anti-SFTSV interventions remain unavailable. Here, utilizing single-cell RNA sequencing (scRNA-seq) and flow cytometry data, we revealed that the deficiency and dysfunction states of T cells, particularly the impaired cytotoxicity and exhausted state of CD4

Indexed as

Antibodies, BispecificPhlebovirusSevere Fever with Thrombocytopenia SyndromeT-LymphocytesViral Envelope ProteinsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLAntibodies, BispecificViral Envelope Proteinsantiviralsbispecific T cell engagersevere fever with thrombocytopenia syndrome virusT cell cytotoxicityT cell exhaustion

Identifiers

PMID41260206
PMCPMC12711666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.