Evidence map›Paper›PMID 41259525›Full record

ArticleScience advances2025

Oral delivery of aptamer-decorated SICTERS Raman probes for colonoscopy-guided resection and photothermal immunization of microtumors.

Xinyi Li, Yuanyuan Qiu, Kai Cui, Wenxian Zhang, Linley Li Lin, Wei Hao, Aoxiang Luo, You Guo, Huan Liu, Wenxuan Dong and 1 more

Abstract read
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In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinyi LiDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.ORCID 0009-0008-9586-6291
Yuanyuan QiuDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.ORCID 0009-0005-2028-2863
Kai CuiDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.
Wenxian ZhangDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.
Linley Li LinState Key Laboratory of Systems Medicine for Cancer, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.ORCID 0000-0002-8079-5768
Wei HaoDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.
Aoxiang LuoDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.
You GuoDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.ORCID 0009-0007-1217-4306
Huan LiuDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.ORCID 0009-0003-3454-3345
Wenxuan DongDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.ORCID 0000-0003-1646-7943
Zeyu XiaoDepartment of Pharmacology and Chemical Biology, and Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P. R. China.ORCID 0000-0002-3457-5772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopic resection of colon cancer represents an advanced technique in early intervention, but faces the challenges in identifying tumor margins and removing residual lesions. Here, we developed orally administered Raman probes (i.e., BBT-Apt@CS NPs) that enable precise tumor imaging and photothermal ablation. Protected by an enteric coating for colon-targeted release, the inner nanoparticles use a stacking-induced charge transfer-enhanced Raman scattering (SICTERS) mechanism and are functionalized with tumor-targeting aptamers. In a proof-of-concept study using the endoscopic optical fiber, we achieved in situ precise detection of microtumors and effective photothermal ablation of residual lesions at the resection margins, with simultaneous induction of immune memory. In a rechallenge model, mice treated with photothermal therapy on residual lesions exhibited no tumor recurrence. We have optimized endoscopic resection strategies through theranostic Raman probes, thus providing an innovative solution for the minimally invasive precision intervention in colorectal cancer.

Indexed as

Aptamers, NucleotideColonic NeoplasmsColonoscopyPhotothermal TherapySpectrum Analysis, RamanAdministration, OralAnimalsCell Line, TumorColorectal NeoplasmsHumansMiceNanoparticlesAptamers, Nucleotide

Identifiers

PMID41259525
PMCPMC12629186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.