Evidence map›Paper›PMID 41259523›Full record

ArticleScience advances2025

The nonfibrillar multiplexin collagen CLE-1 defines cholinergic synapse identity.

Melissa Cizeron, Anaïs Dumas, Suzanne Le Reun, Laure Granger, Maëlle Jospin, Oceane Romatif, Camille Vachon, Delphine Le Guern, Aurore-Cecile Valfort, Jean-Louis Bessereau

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Melissa CizeronUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.ORCID 0000-0002-2124-1917
Anaïs DumasUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.ORCID 0009-0009-4167-9893
Suzanne Le ReunUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.
Laure GrangerUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.
Maëlle JospinUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.
Oceane RomatifUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.ORCID 0009-0004-5182-9772
Camille VachonUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.ORCID 0009-0001-6795-7267
Delphine Le GuernUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.
Aurore-Cecile ValfortUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.ORCID 0000-0001-9594-8694
Jean-Louis BessereauUniversité Claude Bernard Lyon 1, CNRS UMR5284, Inserm U1314, MeLiS, Lyon 69008, France.ORCID 0000-0002-3088-7621

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Fast neurotransmission requires the coordinated localization of neurotransmitter receptors opposite presynaptic release sites, which usually relies on the transsynaptic interaction of synaptic adhesion molecules. However, some extracellular proteins have been shown to coordinate pre- and postsynaptic differentiation by more elusive mechanisms. Here, we identify the nonfibrillar collagen CLE-1, a member of the evolutionarily conserved multiplexin family, as a master determinant of synapse identity in

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsCholinergic NeuronsCollagenSynapsesAnimalsMotor NeuronsNerve Tissue ProteinsNeuromuscular JunctionReceptors, CholinergicSynaptic TransmissionCaenorhabditis elegans ProteinsCollagenMADD-4 protein, C elegansNerve Tissue ProteinsReceptors, Cholinergic

Identifiers

PMID41259523
PMCPMC13142758

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.