ArticleScience advances2025
3D necroprinting: Leveraging biotic material as the nozzle for 3D printing.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
Nature has long inspired engineering innovations. Recent advances in biohybrid research have taken this inspiration further by directly integrating biotic materials into engineered systems. Here we report "3D necroprinting," a biohybrid manufacturing technique that repurposes female mosquito proboscides as high-resolution 3D printing nozzles. The mosquito proboscis, with its unique geometry, structure, and mechanics, enables printed line widths as fine as 20 μm, surpassing commercially available 36-gauge dispense tips by ~100%. The mosquito proboscis dispense tip can withstand internal pressures of approximately 60 kPa, enabling effective fluid extrusion. Demonstrated applications include high-resolution printing of complex structures such as a honeycomb structure, a maple leaf, and bioscaffolds encapsulating cancer cells and red blood cells, showcasing the versatility and capacity of 3D necroprinting. By introducing biotic materials as viable substitutes to complex engineered components, this work paves the way for sustainable and innovative solutions in advanced manufacturing and microengineering.
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