Evidence map›Paper›PMID 41259372›Full record

ArticlePLOS global public health2025

A realist evaluation of a novel cervical cancer prevention strategy in Iquitos, Peru.

Valerie A Paz-Soldan, Lauren Nussbaum, Joanna Brown, Graciela Meza-Sanchez, Sarah D Gilman, J Kathleen Tracy, Patti E Gravitt

Abstract read
In one paragraph

Article in PLOS global public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Valerie A Paz-SoldanDepartment of Tropical Medicine and Infectious Disease, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.ORCID https://orcid.org/0000-0002-1065-4919
Lauren NussbaumDepartment of Tropical Medicine and Infectious Disease, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
Joanna BrownAsociación Benéfica Prisma, Lima, Peru.
Graciela Meza-SanchezFacultad de Medicina Humana, Universidad Nacional de la Amazonía Peruana, Iquitos, Peru.
Sarah D GilmanSchool of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, United States of America.
J Kathleen TracyLarner College of Medicine, University of Vermont, Burlington, Vermont, United States of America.
Patti E GravittDepartment of Epidemiology and Public Health, University of Maryland, Baltimore, Maryland, United States of America.

Funding

Translating Molecular Diagnostics for Cervical Cancer Prevention into PracticeR01CA190366 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI PAZ-SOLDAN, VALERIE ANDREA, TRACY, J. KATHLEEN · 2016 to 2020
$2.7M
NCI NIH HHS R01 CA190366
6 · The paper itself

Abstract

Proyecto Precancer is an implementation science and systems-thinking project with the objective of facilitating the adoption of a new screen-and-treat intervention for cervical cancer prevention in Iquitos in the Peruvian Amazon basin. This intervention introduced human papillomavirus molecular testing and shifted treatment from the tertiary level to the primary level through visual assessment for treatment and thermal ablation for those eligible. To inform how we scale up this pilot project to new regions in Peru in collaboration with the Ministry of Health, we conducted this realist evaluation to learn what worked in our pilot intervention in Iquitos, in what circumstances, for whom, and why. We developed four initial program theories, tested them through interviews with 32 stakeholders, we refined the four program theories based on the interviews, and added a fifth theory. This evaluation revealed that continuous engagement with providers in a horizontal manner across the systems' professional hierarchies (Program Theories 1, 4, and 5) and centering patients with a more convenient and accessible continuum of care can, ultimately, lead to improved screening and treatment rates and reduced patient loss to follow-up (Theories 2 and 3). Furthermore, we learned from our collaborators that embedded research within the public health system had high potential for sustainability due to local ownership. These insights will inform our work as this project assists the Ministry of Health in adapting and scaling up the intervention in other parts of Peru.

Identifiers

PMID41259372
PMCPMC12629488

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.