Evidence map›Paper›PMID 41259290›Full record

ArticleJournal of medicinal chemistry2025

Inverse Correlation between Endoplasmic Reticulum Stress Intensity and Antitumor Immune Response with Ruthenium(II)-Based Photosensitizers for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinoma.

Chloé Thibaudeau, Cyril Bour, Matthieu Scarpi-Luttenauer, Pierre Mesdom, Johannes Karges, Albert Gandioso, Lei Zhou, Sébastien Harlepp, Alexandre Detappe, Mickaël Burgy and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chloé ThibaudeauLaboratoire de Biologie Tumorale, Institut de Cancérologie Strasbourg Europe, 67000 Strasbourg, France.
Cyril BourLaboratoire de Biologie Tumorale, Institut de Cancérologie Strasbourg Europe, 67000 Strasbourg, France.ORCID 0000-0001-6296-7653
Matthieu Scarpi-LuttenauerChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.
Pierre MesdomChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.
Johannes KargesChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.ORCID 0000-0001-5258-0260
Albert GandiosoChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.
Lei ZhouChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.
Sébastien HarleppLaboratoire de Recherche Nanotranslationelle, Institut de Cancérologie Strasbourg Europe, 67000 Strasbourg, France.ORCID 0000-0001-8891-7953
Alexandre DetappeLaboratoire de Recherche Nanotranslationelle, Institut de Cancérologie Strasbourg Europe, 67000 Strasbourg, France.
Mickaël BurgyLaboratoire de Biologie Tumorale, Institut de Cancérologie Strasbourg Europe, 67000 Strasbourg, France.
Sophie MartinLaboratoire de Bioimagerie et Pathologies, OnKO3T, Faculté de Pharmacie, Université de Strasbourg, UMR 7021 CNRS, 67401 Illkirch, France.
Georg MellitzerINSERM UMR 1260, Regenerative Nanomedicine, 67000 Strasbourg, France.
Christian GaiddonLaboratoire Streinth, UMR7242 CNRS, Biotechnologie et Signalisation Cellulaire, 67412 Illkirch Cedex, France.ORCID 0000-0003-4315-3851
Gilles GasserChimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, 75005 Paris, France.ORCID 0000-0002-4244-5097
Alain C JungLaboratoire de Biologie Tumorale, Institut de Cancérologie Strasbourg Europe, 67000 Strasbourg, France.ORCID 0000-0002-4049-4151

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is a promising strategy for head and neck squamous cell carcinoma (HNSCC), but the immune consequences of tumor cell death remain incompletely understood. We compared two ruthenium(II) polypyridine photosensitizers (PSs) in HNSCC models and found that both were potently phototoxic (nanomolar IC

Indexed as

Antineoplastic AgentsEndoplasmic Reticulum StressHead and Neck NeoplasmsPhotochemotherapyPhotosensitizing AgentsRutheniumSquamous Cell Carcinoma of Head and NeckAnimalsApoptosisCell Line, TumorCoordination ComplexesHumansMiceAntineoplastic AgentsCoordination ComplexesPhotosensitizing AgentsRuthenium

Identifiers

PMID41259290
PMCPMC12703731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.