ArticleThe Journal of clinical endocrinology and metabolism2026
Impact of Subtype Variability on Clinical Features in Papillary Thyroid Cancer.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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- Erratum issued
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8 authors.
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Abstract
contextThyroid cancer comprises multiple subtypes and is broadly classified as aggressive or nonaggressive. While many studies have analyzed the clinical features of aggressive and nonaggressive subtypes, to the best of our knowledge, no study has focused on patients having more than 1 subtype concomitantly.
objectivesWe investigated the clinical features manifested when these subtypes and conventional types of thyroid cancer occur simultaneously in the same patient.
methodsIn this single-center, cross-sectional study, we analyzed 26 449 patients with thyroid cancer who underwent surgery for papillary thyroid cancer (PTC) between March 2009 and December 2021 in Korea. We categorized the patients into 5 groups according to the subtypes of PTC (conventional, aggressive, nonaggressive, conventional with aggressive, and conventional with nonaggressive). We compared the patient characteristics and clinical features among the groups and analyzed them statistically.
resultsSignificant differences among the groups were observed based on the PTC subtypes. Patients with both conventional and aggressive subtypes exhibited more aggressive clinical features compared to those with the conventional subtype alone. In the same context, patients with both conventional and nonaggressive subtypes showed aggressive features compared to those with the nonaggressive subtype alone.
conclusionWe concluded that patients with mixed subtypes had clinical features that were more severe than those with a single subtype, suggesting that postoperative management warrants caution.
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