Article in The Journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Tianqi Wang *Department of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0001-9403-0099
Daniel H Kim *Department of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0009-0004-2592-6026
Chang Ding *Department of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0009-0001-3886-9575
Dingxun WangDepartment of Comparative Pathobiology, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0009-0005-3827-620X
Weiwei ZhangDepartment of Botany and Plant Pathology, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0002-4754-6241
Martin SilicDepartment of Comparative Pathobiology, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0003-3433-3922
Xi ChengDepartment of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0002-6706-213X
Kunming ShaoDepartment of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0009-0007-2395-6821
TingHsuan KuDepartment of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0009-0007-6505-3399
Conwy ZhengDepartment of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0009-0002-2891-8908
Junkai XieDavidson School of Chemical Engineering, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0009-0001-8758-3741
Shulan XiaoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0003-4224-4196
Krishna JayantWeldon School of Biomedical Engineering, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0003-4353-6123
Chongli YuanDavidson School of Chemical Engineering, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0003-3765-0931
Alexander A ChubykinDepartment of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0001-8224-9296
Christopher J StaigerDepartment of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0003-2321-1671
GuangJun ZhangDepartment of Comparative Pathobiology, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0002-0839-5161
Qing DengDepartment of Biological Sciences, Purdue University, West Lafayette, West Lafayette, IN, USA.ORCID 0000-0002-9254-9951
Funding
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Role of microRNAs in neutrophil migrationR35GM119787 · NIGMS · PURDUE UNIVERSITY · PI Qing Deng · 2016 to 2026
$4.9M
Roles of ion-channel mediated bioelectricity in developmental patterningR35GM124913 · NIGMS · PURDUE UNIVERSITY · PI GuangJun Zhang · 2017 to 2026
$4.2M
Emergent Mechanisms in Biology of Robustness Integration and Organization Institute #2120200National Science Foundation #2120200NCI NIH HHS P30 CA023168NIGMS NIH HHS R35 GM119787NIGMS NIH HHS R35 GM124913NIH HHS R35GM119787NIH HHS R35GM-124913Purdue University Center for Cancer Research P30CA023168
6 · The paper itself
Abstract
Potassium channels control membrane potential and various physiological processes, including cell migration. However, the specific role of inwardly rectifying potassium channels in immune cell chemotaxis remains unknown. Here, we demonstrate that inwardly rectifying potassium channels, particularly Kir7.1 (Kcnj13), maintain the resting membrane potential and are crucial for directional sensing during neutrophil chemotaxis. Blocking or knocking out Kir in neutrophils disrupted their ability to sense direction toward different chemoattractants in multiple models. Using genetically encoded voltage indicators, we observed oscillating hyperpolarization during tail retraction in zebrafish neutrophils, with Kir7.1 required for depolarization toward the chemokine source. Focal depolarization via optogenetics biased pseudopod selection and triggered new protrusions, which depended on Gα signaling. Global hyperpolarization caused neutrophils to stall migration. Additionally, Kir influences GPCR signaling activation in dHL-60 cells. This research introduces membrane potential as a key component of the complex feedforward mechanism that links the adaptive and excitable networks necessary to guide immune cells in challenging tissue environments.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Inwardly rectifying potassium channels promote directional sensing during neutrophil chemotaxis. · full record | OpenQuestion