Evidence map›Paper›PMID 41258991›Full record

ReviewInternational urology and nephrology2026

Penile cancer and lymph node management: a call for standardization.

Achille Aveta, Vincenzo Iossa, Gianluca Spena, Roberto Contieri, Alessandro Izzo, Francesco Passaro, Antonio Tufano, Vittorio Imperatore, Sisto Perdonà, Lorenzo Romano and 12 more

Abstract readReview
In one paragraph

Review in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Achille Aveta *Department of Urology, Istituto Nazionale Tumori IRCCS, "Fondazione G. Pascale", Naples, Italy.
Vincenzo Iossa *Department of Urology, Azienda Ospedaliera "S.G. Moscati", Avellino, Italy.
Gianluca SpenaDepartment of Urology, Istituto Nazionale Tumori IRCCS, "Fondazione G. Pascale", Naples, Italy.
Roberto ContieriDepartment of Urology, Istituto Nazionale Tumori IRCCS, "Fondazione G. Pascale", Naples, Italy.
Alessandro IzzoDepartment of Urology, Istituto Nazionale Tumori IRCCS, "Fondazione G. Pascale", Naples, Italy.
Francesco PassaroDepartment of Urology, Istituto Nazionale Tumori IRCCS, "Fondazione G. Pascale", Naples, Italy.
Antonio TufanoDepartment of Urology, San Carlo di Nancy Hospital, Rome, Italy.
Vittorio ImperatoreDepartment of Urology, Azienda Ospedaliera "S.G. Moscati", Avellino, Italy.
Sisto PerdonàDepartment of Urology, Istituto Nazionale Tumori IRCCS, "Fondazione G. Pascale", Naples, Italy.
Lorenzo RomanoDepartment of Woman, Child and General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", 81100, Naples, Italy.
Carlo GiulioniUrology Unit, Villa Igea Private Hospital, Ancona, Italy.
Angelo CafarelliUrology Unit, Villa Igea Private Hospital, Ancona, Italy.
Pierluigi RussoDepartment of Urology, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy.
Fabio CrocerossaDepartment of Urology, Magna Graecia University of Catanzaro, 88100, Catanzaro, Italy.
Francesco LasorsaUrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari "Aldo Moro", 70124, Bari, Italy.
Giuseppe LucarelliUrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari "Aldo Moro", 70124, Bari, Italy.
Matteo FerroUnit of Urology, Department of Health Science, University of Milan, ASST Santi Paolo and Carlo, Via A. Di Rudini 8, 20142, Milan, Italy.
Raffaele BalsamoUrology Unit, AORN Ospedali dei Colli, Monaldi Hospital, 80131, Naples, Italy.
Celeste ManfrediDepartment of Woman, Child and General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", 81100, Naples, Italy.
Davide ArcanioloDepartment of Woman, Child and General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", 81100, Naples, Italy.
Salvatore SiracusanoDepartment of Urology, University of L'Aquila, L'Aquila, Italy.
Savio Domenico PandolfoDepartment of Urology, University of L'Aquila, L'Aquila, Italy. pandolfosavio@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to compare and organize recommendations from the most eminent international guidelines on the staging and treatment of lymph node (LN) involvement in penile cancer (PC). Early recognition and appropriate management of nodal disease remain the cornerstone of care, influencing both survival and treatment-related morbidity.

methodsThis study compares and organize recommendations form the most eminent international guidelines-including NCCN, ESMO-EURACAN, and EAU-ASCO-on the staging and treatment of lymph node involvement in penile cancer.

resultsOpen inguinal LN dissection (ILND) remains the standard treatment for not superficial cancers and its morbidity has driven interest in minimally invasive surgical approaches, such as video-endoscopic inguinal lymphadenectomy (VEIL), including its robot-assisted variant (RA-VEIL). Their role is well defined in clinically node-negative (cN0) patients but remains investigational in node-positive (cN+) cases. For cN3 disease and pelvic node involvement, multimodal strategies including chemotherapy, surgery, and radiotherapy are required.

conclusionThe variability among guidelines underscores the need for collaborative efforts and high-quality prospective trials to refine and standardize treatment recommendations.

Indexed as

Lymph Node ExcisionLymph NodesPenile NeoplasmsPractice Guidelines as TopicHumansLymphatic MetastasisMaleNeoplasm StagingInguinal lymph node dissectionLymph node managementPenile cancerpenile cancer guidelines

Identifiers

PMID41258991
PMCPMC13121237

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.