Evidence map›Paper›PMID 41258963›Full record

ReviewSports medicine (Auckland, N.Z.)2026

From Strain to Repair: A Targeted Review of Lipid Mediators Driving the Inflammatory Cascade Following Exercise.

Saurabh Satija, Todd W Mitchell, Ryan Anthony, Gregory E Peoples, John A Sampson

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saurabh SatijaSchool of Medical, Indigenous & Health Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia.
Todd W MitchellSchool of Medical, Indigenous & Health Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia. toddm@uow.edu.au.
Ryan AnthonyGraduate School of Medicine, University of Wollongong, Wollongong, NSW, Australia.
Gregory E PeoplesHealth Innovations, Faculty of Science, Medicine & Health, University of Wollongong, Wollongong, NSW, Australia.
John A SampsonSchool of Medical, Indigenous & Health Sciences, University of Wollongong, Northfields Avenue, Wollongong, NSW, 2522, Australia. jsampson@uow.edu.au.ORCID 0000-0002-6800-7757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise triggers a proportional inflammatory response that is crucial for muscle fiber repair and adaptation. However, excessive or chronic inflammation can delay recovery and increase injury risk. Biomarkers such as creatine kinase and interleukins are commonly used to assess muscle damage and inflammation, respectively, but they have limitations in specificity and sensitivity. However, lipid mediators that signal all inflammatory events with distinct roles in pro-inflammatory, anti-inflammatory, and pro-resolving phases could provide a more complete understanding of the inflammatory response to exercise. In this review, we discuss the limitations of current biomarkers and the potential of lipid mediators to theoretically offer more precise insights into the inflammatory processes following exercise. Further research is needed to establish standardized protocols for measuring lipid mediators and to understand their temporal dynamics in relation to inflammation and recovery. This knowledge could lead to improved strategies for monitoring and enhancing recovery in athletes.

Indexed as

ExerciseInflammationInflammation MediatorsMuscle, SkeletalBiomarkersHumansLipid MetabolismBiomarkersInflammation Mediators

Identifiers

PMID41258963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.