Evidence map›Paper›PMID 41258948›Full record

ArticleJournal of autism and developmental disorders2025

Age-Dependent Process Governs Executive Function Disability in Autistic Children.

Andrey Vyshedskiy, Allegra Marsiglio, Sahil Batham, Alessandro Tagliavia, Rohan Venkatesh, Anel Tarakbay, Sagar Mundhia, Samarth Urs, Edward Khokhlovich, Eugene Pinsky

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Article in Journal of autism and developmental disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Andrey VyshedskiyBoston University, Boston, MA, 02215, USA. vysha@bu.edu.ORCID http://orcid.org/0000-0002-1610-8716
Allegra MarsiglioBoston University, Boston, MA, 02215, USA.
Sahil BathamBoston University, Boston, MA, 02215, USA.
Alessandro TagliaviaBoston University, Boston, MA, 02215, USA.
Rohan VenkateshIndependent researcher, Newton, MA, 02459, USA.
Anel TarakbayBoston University, Boston, MA, 02215, USA.
Sagar MundhiaBoston University, Boston, MA, 02215, USA.
Samarth UrsBoston University, Boston, MA, 02215, USA.
Edward KhokhlovichIndependent researcher, Newton, MA, 02459, USA.
Eugene PinskyBoston University, Boston, MA, 02215, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeComprehension of syntactic language is facilitated by the executive function of Prefrontal Synthesis (PFS), defined as an ability to deliberately modify and juxtapose mental visuospatial objects. Autistic individuals often experience deficits in PFS. This study aimed to differentiate between two hypotheses regarding PFS acquisition. The first suggests a persistent, age-independent barrier that continuously hinders PFS development. The second proposes an age-dependent factor, such as a critical period for PFS acquisition. These hypotheses predict distinct learning trajectories: the first expects autistic individuals to exhibit a consistently slower PFS-learning rate across all ages, while the second predicts an initial learning rate comparable to neurotypical peers, followed by an early decline.

methodsTo test these predictions, we analyzed PFS development in 15,183 autistic and 138 neurotypical individuals aged 2 to 22 years using parent-reports.

resultsAt age 2, both groups exhibited similar PFS-learning rates. In neurotypical individuals, this rate remained high until age 7. However, in autistic individuals, learning rates began to decline exponentially as early as 2.3 years, with an even earlier onset in those with severe autism.

conclusionThese findings support the second hypothesis, suggesting that PFS deficits in autism may stem from an age-dependent factor, such as a shortened critical period.

Indexed as

Critical period, sensitive period, first language acquisitionGrammatical languageLanguage acquisitionRecursive languageSyntactic language

Identifiers

PMID41258948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.