Evidence map›Paper›PMID 41258903›Full record

ArticleJournal of the American Chemical Society2025

Methionine Salvage Enzyme Uses a Unique Mechanism to Overcome a Challenging Aldose-Ketose Isomerization.

Subashi T Ubayawardhana, Tamal Das, Stephanie A Corio, Jennifer S Hirschi, Andrew S Murkin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Subashi T UbayawardhanaDepartment of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.ORCID 0000-0002-8219-7163
Tamal DasDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.ORCID 0009-0002-0420-8178
Stephanie A CorioDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.ORCID 0000-0001-9029-3895
Jennifer S HirschiDepartment of Chemistry, Binghamton University, Binghamton, New York 13902, United States.ORCID 0000-0002-3470-0561
Andrew S MurkinDepartment of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.ORCID 0000-0002-2559-4605

Funding

Mechanistic Investigation into Modern Catalytic ReactionsR35GM147183 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI Jennifer Hirschi · 2022 to 2026
$1.7M
NIGMS NIH HHS R35 GM147183
6 · The paper itself

Abstract

The enzyme-catalyzed interconversion of aldoses and ketoses historically involves one of two mechanisms, both of which require an aldehyde form of the substrate. Methylthio-d-ribose-1-phosphate (MTR1P) isomerase (MtnA), which functions in the methionine salvage pathway, poses a challenge to this canon because its substrate cannot readily access such a form. MtnA must catalyze the opening of the ribofuranose ring and hydrogen transfer between C-2 and C-1. Primary

Indexed as

KetosesMethionineBiocatalysisIsomerismKineticsModels, MolecularKetosesMethionine

Identifiers

PMID41258903
PMCPMC12657062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.