Evidence map›Paper›PMID 41258782›Full record

ArticlePharmacology research & perspectives2025

Effects of Botrychium ternatum (Thunb) Sw. On Cytochrome P450 Activities in Rats.

Jiange Yao, Liming Hu, Quan Zhou, Abdullah Al Mamun, Shuanghu Wang, Aixia Han

Abstract read
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In one paragraph

Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiange YaoDepartment of Outpatient, The Fifth Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Liming HuDepartment of Pharmacy, The First People's Hospital of Wenling, Zhejiang, China.
Quan ZhouKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, Central Laboratory of the Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Zhejiang, China.
Abdullah Al MamunKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, Central Laboratory of the Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Zhejiang, China.ORCID 0000-0001-9936-3925
Shuanghu WangKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, Central Laboratory of the Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Zhejiang, China.ORCID 0000-0002-0057-267X
Aixia HanKey Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, Central Laboratory of the Lishui Hospital of Wenzhou Medical University, the First Affiliated Hospital of Lishui University, Lishui People's Hospital, Zhejiang, China.

Funding

Wenling City Science and Technology Project (2021S00198 and 2023S00090), Public Welfare Technology Research Funding Project of Zhejiang (LLSSY24H160003 & LTGY24H100002), Municipal public welfare self-financing technology application research project of Lishui (2022SJZC079)
6 · The paper itself

Abstract

Drug interactions commonly occur through the activities of cytochrome P450 (CYP). In this study, we evaluated the effects of the Chinese herbal medicine Botrychium Ternatum (Thunb) Sw. (BT) on six CYP enzymes. Twelve healthy male Sprague-Dawley rats were randomly divided into two groups (n = 6 each), which were administered the same doses of the probe drugs via gavage. Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was performed to detect the plasma concentrations of the probe drugs and their metabolites. Serum biochemical indicators in rats were analyzed to determine the effect of BT on hepatocytes and their anabolism. Real-time fluorescence quantitative PCR was performed to assess the expression level of enzymes. The BT group showed lower AUC

Indexed as

Cytochrome P-450 Enzyme SystemDrugs, Chinese HerbalAnimalsAspartate AminotransferasesHepatocytesHerb-Drug InteractionsMaleRatsRats, Sprague-DawleyTandem Mass SpectrometryAspartate AminotransferasesCytochrome P-450 Enzyme SystemDrugs, Chinese HerbalBotrychium ternatum (Thunb) Sw.CYPdrug–drug interactionultra‐performance liquid chromatography–tandem mass spectrometry

Identifiers

PMID41258782
PMCPMC12628597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.