ArticleInvestigative ophthalmology & visual science2025
Visuo-Cognitive Executive Functions in Amblyopia and Strabismus: Associations With Function and Quality of Life.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Binocular Vision Anomalies: An Update on Prevalence, Impact, Technological and Treatment Developments and Current Challenges.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Review
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Authors and funding
4 authors.
Funding
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Abstract
Purpose: The purpose of this study was to evaluate higher-order visual processing and executive function in adults with amblyopia and/or strabismus under habitual binocular viewing conditions and to explore their association with functional capabilities and vision-related quality of life (VRQOL). Methods: This study included 114 adults (23 with amblyopia, 52 with amblyopia and strabismus, 20 with strabismus, and 19 healthy controls). Assessments included visual acuity and binocular function score (BFS), visuo-cognitive tests (Useful Field of View [UFOV], Trail Making Test [TMT], and Stroop Color and Word Test [SCWT]), and functional tests (fine motor skills [FMS] and reading rate). Group differences were evaluated using ANOVA, and regression models assessed the contribution of clinical and cognitive measures to functional outcomes and VRQOL. Results: Performance significantly varied across groups (F(3,108) = 753, P < 0.001), for all three visuo-cognitive tests (UFOV F(3,108) = 2.982, P = 0.034; TMT F(3,108) = 5.289, P = 0.002; and SCWT F(3,108) = 4.068, P = 0.009). Adults with amblyopia and/or strabismus had significantly slower completion times on UFOV, TMT, and SCWT compared with healthy controls (P < 0.05), with pronounced deficits in divided attention, visual search, and cognitive flexibility. Performance among the three visuo-cognitive tests was strongly correlated (r's³ = 0.7, P = 0.01). Regression analyses revealed that SCWT times significantly predicted FMS and reading speed, explaining 42% and 31% of the variance, respectively. Psychosocial VRQOL scores were significantly influenced by the presence of strabismus (P = 0.001), whereas functional impact scores were associated with BFS (P = 0.04) and UFOV times (P = 0.02). Conclusions: Amblyopia and/or strabismus in adults are associated with executive function deficits, poorer functional performance, and reduced VRQOL. These findings highlight the long-term visuo-cognitive and functional consequences of abnormal visual development and underscore the need for targeted interventions.
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