ArticleDiscover oncology2025
WNT6 promotes choriocarcinoma progression by driving proliferation, invasion, and metastasis.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveChoriocarcinoma has a high propensity for distant metastasis, imposing a substantial psychological burden on patients. Unveiling the molecular mechanisms underlying tumor invasion and metastasis holds great clinical significance.
methodsImmunohistochemistry was employed to detect WNT6 expression in normal early pregnancy villi, regressive hydatidiform moles, malignant hydatidiform moles and gestational trophoblastic neoplasia. Quantitation of mRNA expression by real-time PCR and Western blotting were utilized to quantify WNT6 expression in human chorionic trophoblastic cells and choriocarcinoma cells. Lentiviruses were used to construct stable cell models with either overexpressed or knocked-down WNT6, aiming to explore the impact of WNT6 expression on cell proliferation, migration, and invasion.
resultsThe expression of WNT6 was significantly higher in malignant tissues and cells compared to normal counterparts. In the malignant hydatidiform mole group, WNT6 expression was correlated with tumor metastasis and the FIGO anatomical stage. Kaplan-Meier survival curve analysis indicated that the disease progression time of the high-WNT6-expression subgroup in the malignant hydatidiform mole group was notably shorter than that of the low-expression subgroup. CCK-8 assay, wound healing assay, and Transwell assays demonstrated that overexpression of WNT6 could enhance the proliferation, migration, and invasion of HTR-8 cells. Conversely, interfering with WNT6 expression led to opposite outcomes.
conclusionHigh WNT6 expression is associated with tumor progression and poor prognosis. WNT6 is involved in the development of gestational trophoblastic diseases and can serve as a reference biomarker for disease progression and prognosis assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.