ArticleIrish journal of medical science2026
Impact of vitamin D deficiency on disease outcomes in patients with oral squamous cell carcinoma: a retrospective cohort study.
Article in Irish journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundVitamin D deficiency has been associated with poorer outcomes in patients with colorectal and breast carcinomas. This study aimed to explore the relationship between serum vitamin D levels and clinicopathological features in patients with oral squamous cell carcinoma (OSCC).
methodsSerum vitamin D levels were measured in 150 OSCC patients (mean age: 65 years) at the time of diagnosis and categorized as normal or low. Data on tumour T-stage, nodal involvement, perineural invasion, recurrence, metastasis were collected and analysed over a two-year follow-up period.
resultsOf the 150 patients, 70 (46.7%) had low vitamin D levels. Patients with lower vitamin D levels were significantly more likely to exhibit advanced disease features, including nodal involvement (p < 0.01), distant metastases, and perineural invasion (p = 0.02). Low vitamin D levels were also associated with tumour location in common sites of the oral cavity. Seasonal variation did not significantly impact vitamin D levels in this cohort.
conclusionsThe study demonstrates a significant correlation between low serum vitamin D levels and aggressive tumour behaviour in OSCC, including increased nodal spread, perineural invasion, and metastasis. These findings suggest that vitamin D levels may serve as a prognostic marker in OSCC and highlight the need for further research into its potential therapeutic role.
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