Patterns of ipsilateral breast tumor recurrence following partial vs. whole-breast irradiation: a retrospective comparative study of breast-conserving therapy.

Kazuhiko Sato, Hiromi Fuchikami, Naoko Takeda, Nana Natsume, Masahiro Kato

Abstract readComparative Study

In one paragraph

Article in Breast cancer (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Kazuhiko SatoDepartment of Breast Oncology, Tokyo-West Tokushukai Hospital, Tokyo, Japan. kazsato.boc@gmail.com.ORCID http://orcid.org/0000-0002-0380-1693

Hiromi FuchikamiDepartment of Breast Oncology, Tokyo-West Tokushukai Hospital, Tokyo, Japan.

Naoko TakedaDepartment of Breast Oncology, Tokyo-West Tokushukai Hospital, Tokyo, Japan.

Nana NatsumeDepartment of Radiation Oncology, Tokyo-West Tokushukai Hospital, Tokyo, Japan.

Masahiro KatoDepartment of Radiation Oncology, Tokyo-West Tokushukai Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePartial-breast irradiation (PBI) is an alternative to whole-breast irradiation (WBI) in breast-conserving therapy. This study evaluated the incidence and temporal patterns of ipsilateral breast tumor recurrence (IBTR), classified as true recurrence (TR) or new primary tumor (NP), and compared the impact of PBI and WBI. METHODS AND MATERIALS: We retrospectively analyzed 1,395 patients treated with PBI or WBI between 2008 and 2024. PBI was delivered perioperatively using multicatheter interstitial brachytherapy (32 Gy in 8 fractions or 25.2 Gy in 4 fractions) or WBI (50 Gy in 25 fractions). The incidence, timing, and predictors of TR and NP were evaluated.

resultsAt a median follow-up of 6.7 years, 40 IBTRs (2.9%) occurred: 20 TRs (1.4%) and 20 NPs (1.4%). Five- and 10-year breast cancer-specific survival rates were 85.4% and 60.1% for TR, and 100% and 100% for NP (p < 0.01). TR rates were similar between the PBI and WBI cohorts (1.4% vs. 1.6%, p = 0.68), but NP occurred more frequently after PBI (1.9% vs. 0.5%, p = 0.04). Multivariate analysis revealed that younger age (< 50 years) was independently associated with TR (HR, 2.51; p = 0.01), and PBI was significantly associated with NP (HR, 4.44; p < 0.01).

conclusionsPBI provides local control comparable to WBI for TR; however, it may be associated with an increased risk of NP, which represents a potential drawback of PBI.

Indexed as

BrachytherapyBreast NeoplasmsMastectomy, SegmentalNeoplasm Recurrence, LocalNeoplasms, Second PrimaryAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansIncidenceMiddle AgedRadiotherapy, AdjuvantRetrospective StudiesSurvival RateBrachytherapyBreast cancerBreast-conserving therapyIpsilateral breast tumor recurrencePartial-breast irradiation

Identifiers

PMID41258584

DOI10.1007/s12282-016-0669-4

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.