Evidence map›Paper›PMID 41258568›Full record

ArticleCellular and molecular life sciences : CMLS2025

Prolyl endopeptidase is a multifunctional host factor required for FMDV infection.

Kun Ma, Rongzeng Hao, Tianran Liu, Yi Ru, Tao Feng, Xiaolan Qi, Yuzhe Wang, Bingzhou Lu, Sen Wu, Dan Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kun Ma *Frontiers Science Center for Molecular Design Breeding, State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China.
Rongzeng Hao *State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Tianran LiuFrontiers Science Center for Molecular Design Breeding, State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China.
Yi RuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Tao FengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Xiaolan QiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Yuzhe WangFrontiers Science Center for Molecular Design Breeding, State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China.
Bingzhou LuState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Sen WuFrontiers Science Center for Molecular Design Breeding, State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China.
Dan LiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
Ran ZhangFrontiers Science Center for Molecular Design Breeding, State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China. zhangran0628@cau.edu.cn.ORCID http://orcid.org/0000-0002-3452-8917
Yaofeng ZhaoFrontiers Science Center for Molecular Design Breeding, State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, 100193, China. yaofengzhao@cau.edu.cn.
Haixue ZhengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China. haixuezheng@163.com.

Funding

Biological Breeding-National Science and Technology Major Project 2023ZD04043National Key Research and Development Program of China 2023YFF1000900National Natural Science Foundation of China 32272839National Natural Science Foundation of China 32372990Project of National Center of Technology Innovation for Pigs NCTIP-XD/C03The 2115 Talent Development Program of China Agricultural University The 2115 Talent Development Program of China Agricultural UniversityThe earmarked fund for CARS-35 The earmarked fund for CARS-35The open competition program of top ten critical priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province 2022SDZG02
6 · The paper itself

Abstract

Foot-and-mouth disease virus (FMDV) poses a significant global threat to livestock production, underscoring the urgent need for a deeper understanding of virus-host interactions to develop effective prevention strategies. In this study, we identify prolyl endopeptidase (PREP) as a critical host factor in FMDV infection. We demonstrate that PREP knockout (PREP-KO) significantly enhances host resistance to FMDV infection by upregulating the expression of RIG-I and MDA5 mRNA. Specifically, PREP-KO destabilizes the PUM1 protein via proteasomal and apoptotic degradation pathways, thereby increasing RIG-I promoter activity. Additionally, PREP-KO inhibits the FMDV life cycle at the replication stage. In vivo experiments further reveal that PREP inhibition or knockout provides protection against FMDV infection following a sublethal challenge in mice. Our findings identify PREP as a novel antiviral target, providing valuable insights for development of antiviral therapies and breeding of disease-resistant livestock.

Indexed as

Foot-and-Mouth DiseaseFoot-and-Mouth Disease VirusHost-Pathogen InteractionsProlyl OligopeptidasesSerine EndopeptidasesAnimalsDEAD Box Protein 58HumansInterferon-Induced Helicase, IFIH1MiceRNA-Binding ProteinsVirus ReplicationDEAD Box Protein 58Interferon-Induced Helicase, IFIH1Prolyl OligopeptidasesRNA-Binding ProteinsSerine EndopeptidasesFoot-and-mouth disease virusInnate immunityProlyl endopeptidasePumilio protein 1Virus life cycle

Identifiers

PMID41258568
PMCPMC12630515

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.